Detailed information of TA system TA079814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2827704..2829292
• Replicon: chromosome
• Accession: NZ_CP022823
• Organism: Klebsiella quasivariicola strain KPN1705

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: B8P98_RS14100
• Protein ID: WP_025713159.1
• Coordinates: 2827704..2829026 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1F2MCN9
• Locus tag: B8P98_RS14105
• Protein ID: WP_008804920.1
• Coordinates: 2829026..2829292 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B8P98_RS14085	2822769..2825270	+	2502	WP_025713156.1	fimbrial biogenesis outer membrane usher protein	-
B8P98_RS14090	2825258..2826262	+	1005	WP_025713157.1	type 1 fimbrial protein	-
B8P98_RS14095	2826395..2827687	+	1293	WP_025713158.1	glycoside hydrolase family 10 protein	-
B8P98_RS14100	2827704..2829026	-	1323	WP_025713159.1	type II toxin-antitoxin system HipA family toxin	Toxin
B8P98_RS14105	2829026..2829292	-	267	WP_008804920.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
B8P98_RS14110	2829532..2829858	-	327	WP_095033147.1	hydroxyisourate hydrolase	-
B8P98_RS14115	2829855..2830355	-	501	WP_095033148.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
B8P98_RS14120	2830333..2831712	-	1380	WP_095033149.1	purine permease	-
B8P98_RS14125	2832058..2833212	+	1155	WP_025713163.1	FAD-dependent urate hydroxylase HpxO	-
B8P98_RS14130	2833193..2834116	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48929.24 Da
• Isoelectric Point: 8.2552

>T79814 WP_025713159.1 NZ_CP022823:c2829026-2827704 [Klebsiella quasivariicola]
MATLITWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSTQPFDLLAEVGRDSVGAVTLLPPGEEAYLEALRWQTLDEAQLTSLLTAYQSDIPLGMVNGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMSFLLGSSEALKDRADFMKFMVFQWLAGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILNEFAGRVP
QAIDSARRTLPADFSAHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T79814 NZ_CP022823:c2829026-2827704 [Klebsiella quasivariicola]
ATGGCAACGCTTATCACCTGGATGAACAATGTGCGCGTGGGCACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTTCG
CTACGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCACAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCAACGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGCGATAGCGTAGGGGCGGTGACCCTGCTGCCGCCGGG
GGAAGAGGCGTATCTGGAGGCATTGCGCTGGCAGACGCTGGACGAGGCGCAACTCACCTCTCTGCTGACCGCCTACCAGT
CGGATATACCTCTCGGAATGGTGAACGGCCAGGATGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGGACACTGGTGTATTCCGCAGGGCACCACGCCGACCACGCATATCATTAAACTGCCGATCGGCGAGAT
TAAGCAGCCTAATGCAACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTATCTGTGCCTGGCGCTGGCCAGAGCGCTGG
GCCTGGCGGTGCCGGAGGCAGAGATCATCACCACCCCGCGGATCCGCGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCGTTTGGTCTTCCTTCAGCGATGAAATA
CGAGTCCGACGGCGGACCGGGGATCGCCGCGATAATGTCTTTTCTGCTGGGGTCCAGTGAAGCCCTGAAAGACCGCGCTG
ACTTTATGAAATTCATGGTCTTTCAGTGGCTGGCCGGGGCGACGGACGGTCACGCGAAAAACTTCTCAATTTACCTGCTG
CCCGGCGGTAGTTACCGCTTAACGCCGTTCTACGACATTATTTCGGCGTTTCCGGTACTGGGCGGCACGGGTCTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCGATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCAATGAGTTTGCCGGGCGGGTGCCG
CAGGCTATCGACAGCGCCCGCCGGACGCTGCCAGCGGACTTTTCCGCCCACGTCTGGCAGGCCATTACGGAGAATATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGTTGCAGGCGTTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.30 Da
• Isoelectric Point: 8.5912

>AT79814 WP_008804920.1 NZ_CP022823:c2829292-2829026 [Klebsiella quasivariicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT79814 NZ_CP022823:c2829292-2829026 [Klebsiella quasivariicola]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTATCTGAAGCTGCTGCGCCAGCAGAACCACTGGACACA
GGATGCGCTGGCCAGGCGGATCGGTATTAAGCAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAAGCCACAGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1F2MCN9