Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2841556..2842184 Replicon chromosome
Accession NZ_CP022725
Organism Erwinia persicina strain B64

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag CI789_RS13490 Protein ID WP_004156337.1
Coordinates 2841966..2842184 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3S7S5Y4
Locus tag CI789_RS13485 Protein ID WP_062744996.1
Coordinates 2841556..2841936 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI789_RS13455 2836736..2836879 + 144 WP_062745007.1 type B 50S ribosomal protein L36 -
CI789_RS13460 2837141..2838172 + 1032 WP_118664524.1 hypothetical protein -
CI789_RS13465 2838212..2839090 - 879 WP_062745002.1 metal ABC transporter substrate-binding protein -
CI789_RS13470 2839087..2839956 - 870 WP_062745000.1 metal ABC transporter permease -
CI789_RS13475 2839953..2840642 - 690 WP_118665845.1 ATP-binding cassette domain-containing protein -
CI789_RS24220 2841055..2841408 + 354 WP_162900986.1 hypothetical protein -
CI789_RS13485 2841556..2841936 + 381 WP_062744996.1 Hha toxicity modulator TomB Antitoxin
CI789_RS13490 2841966..2842184 + 219 WP_004156337.1 hemolysin expression modulator Hha Toxin
CI789_RS13500 2842476..2842790 + 315 WP_062744994.1 MGMT family protein -
CI789_RS13505 2842819..2843376 - 558 WP_062744992.1 YbaY family lipoprotein -
CI789_RS13510 2843604..2844464 + 861 WP_118664526.1 acyl-CoA thioesterase II -
CI789_RS13515 2844546..2845847 - 1302 WP_118664527.1 ammonium transporter AmtB -
CI789_RS13520 2845867..2846205 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T79652 WP_004156337.1 NZ_CP022725:2841966-2842184 [Erwinia persicina]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T79652 NZ_CP022725:2841966-2842184 [Erwinia persicina]
ATGACAGACAAACTTTTAACGAAAACTGATTATCTTATGCGCCTGAGACGCTGTCGTTCAATCGACACGCTTGAGCGTGT
AATCGAAAAAAACAAATACGAATTATCTGATGACGAACTGGCTGTATTCTATTCGGCTGCGGATCATCGCCTGGCTGAGC
TGACAATGAATAAGCTCTATGACAAAGTGCCTGTGGCAGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14645.29 Da        Isoelectric Point: 4.5911

>AT79652 WP_062744996.1 NZ_CP022725:2841556-2841936 [Erwinia persicina]
MDEYSPRRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSVANLQLNDLIEHIAAFTMNYKIKHIEDVDLISQVDEYL
DDTFTLFSNYGINVQDLQRWQKCAKRLFNIFAEECSTARTQASHSF

Download         Length: 381 bp

>AT79652 NZ_CP022725:2841556-2841936 [Erwinia persicina]
ATGGACGAATACTCACCGAGAAGGCATGATATTGCACAGCTTAAATTCTTATGCGAGAACCTGTACGATGAAAGCCTGGC
GACATTAGGTGACAGCCATCATGGCTGGGTTAACGATCCTACTTCTGTTGCTAATCTTCAGCTTAATGATCTTATCGAGC
ATATTGCAGCCTTTACTATGAATTACAAAATTAAGCACATTGAGGATGTTGACCTGATAAGCCAGGTTGATGAATACCTT
GATGACACTTTCACATTGTTCAGTAATTATGGCATTAATGTTCAGGACTTACAGCGATGGCAGAAATGTGCAAAGCGGCT
GTTCAACATTTTTGCAGAAGAGTGTTCAACGGCACGTACACAGGCCAGCCATTCCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7S5Y4

References