Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2768764..2768973 Replicon chromosome
Accession NZ_CP022524
Organism Clostridioides difficile strain DH/NAP11/106/ST-42

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CGC51_RS13035 Protein ID WP_004454815.1
Coordinates 2768815..2768973 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2768764..2768898 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGC51_RS13015 2764201..2765829 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CGC51_RS13020 2765950..2766945 + 996 WP_003431031.1 asparaginase -
CGC51_RS13025 2767123..2767506 - 384 Protein_2439 BlaI/MecI/CopY family transcriptional regulator -
- 2768764..2768898 + 135 NuclAT_0 - Antitoxin
CGC51_RS13035 2768815..2768973 - 159 WP_004454815.1 hypothetical protein Toxin
CGC51_RS13040 2769267..2770637 - 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
CGC51_RS13045 2770853..2771970 + 1118 Protein_2442 site-specific integrase -
CGC51_RS18845 2772333..2772413 - 81 Protein_2443 VOC family protein -
CGC51_RS13055 2772453..2773121 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T79163 WP_004454815.1 NZ_CP022524:c2768973-2768815 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T79163 NZ_CP022524:c2768973-2768815 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT79163 NZ_CP022524:2768764-2768898 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References