Detailed information of TA system TA079015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4957664..4959237
• Replicon: chromosome
• Accession: NZ_CP022426
• Organism: Aeromonas salmonicida subsp. pectinolytica 34mel

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: T0QVS7
• Locus tag: Asalp_RS23140
• Protein ID: WP_021140475.1
• Coordinates: 4957664..4958983 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: Asalp_RS23145
• Protein ID: WP_021140474.1
• Coordinates: 4958983..4959237 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Asalp_RS23125	4954462..4954713	+	252	WP_005319564.1	isochorismatase	-
Asalp_RS23130	4954889..4956025	+	1137	WP_193557899.1	histidine decarboxylase	-
Asalp_RS23135	4956041..4957072	-	1032	WP_099369089.1	IS630-like element ISAhy2 family transposase	-
Asalp_RS23140	4957664..4958983	-	1320	WP_021140475.1	type II toxin-antitoxin system HipA family toxin	Toxin
Asalp_RS23145	4958983..4959237	-	255	WP_021140474.1	helix-turn-helix domain-containing protein	Antitoxin
Asalp_RS23155	4960145..4960768	+	624	WP_034524237.1	recombinase family protein	-
Asalp_RS23165	4961345..4963327	-	1983	Protein_4404	Tn3 family transposase	-
Asalp_RS23170	4963361..4963918	-	558	WP_003100847.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	basG	4954462..5003862	49400
	-	inside	IScluster/Tn	-	-	4956041..4967334	11293

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49287.28 Da
• Isoelectric Point: 7.1941

>T79015 WP_021140475.1 NZ_CP022426:c4958983-4957664 [Aeromonas salmonicida subsp. pectinolytica 34mel]
MANLAVYMNGYRVGTFTKATSGAHQFQYHGSWLAQPGSRPISLSMPLRHQAYRGNEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGGDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYICTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSAILEGLKTRSARLIKGWD

Nucleotide

• Length: 1320 bp

>T79015 NZ_CP022426:c4958983-4957664 [Aeromonas salmonicida subsp. pectinolytica 34mel]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTGGGCACATTCACCAAAGCTACCAGCGGCGCCCATCAGTTTCA
GTACCATGGGTCATGGCTAGCACAACCGGGCAGCCGTCCCATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCAATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GGGCGATGTTCCTGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAAACTGCG
CTGCTCTATCTCGATGGCCGCTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATTAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATATCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAGCGCTTCGACAGACGT
TACGCAACAGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGCGGACCGGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGCAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGCC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAACGCGTTACCCAGCAATTGCCGGCAGGCTTCCCCGATGCCATCAGCAGCGCCATTCTAGAGGGCCT
AAAAACCCGCTCTGCCAGGCTGATAAAAGGCTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9279.59 Da
• Isoelectric Point: 7.9834

>AT79015 WP_021140474.1 NZ_CP022426:c4959237-4958983 [Aeromonas salmonicida subsp. pectinolytica 34mel]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT79015 NZ_CP022426:c4959237-4958983 [Aeromonas salmonicida subsp. pectinolytica 34mel]
ATGAAAGTAACCAGCGCCAAGCAACTGAGCGCCTGTATCAAGGATGCCAGACTTTCTCAAAAGCTCTCTCAAGGTAAAGT
GGCCGAGAAAGTGGGGATTCGGCAAGACACAGTCTCCAGCTTCGAGCTCAACCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGATAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: T0QVS7