Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1316003..1316801 Replicon chromosome
Accession NZ_CP022393
Organism Escherichia coli strain E62

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CEJ55_RS06725 Protein ID WP_049592807.1
Coordinates 1316003..1316380 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CEJ55_RS06730 Protein ID WP_089180163.1
Coordinates 1316427..1316801 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEJ55_RS06705 1312177..1312713 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
CEJ55_RS06710 1313048..1314583 - 1536 WP_049592737.1 EAL domain-containing protein -
CEJ55_RS06715 1314654..1315499 - 846 WP_089180162.1 DUF4942 domain-containing protein -
CEJ55_RS06720 1315584..1315781 - 198 WP_087891818.1 DUF957 domain-containing protein -
CEJ55_RS25180 1315857..1316006 - 150 Protein_1202 hypothetical protein -
CEJ55_RS06725 1316003..1316380 - 378 WP_049592807.1 TA system toxin CbtA family protein Toxin
CEJ55_RS06730 1316427..1316801 - 375 WP_089180163.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEJ55_RS06740 1316964..1317185 - 222 WP_001601167.1 DUF987 domain-containing protein -
CEJ55_RS06745 1317254..1317730 - 477 WP_001186768.1 RadC family protein -
CEJ55_RS06750 1317746..1318231 - 486 WP_089180164.1 antirestriction protein -
CEJ55_RS06755 1318323..1319141 - 819 WP_049592655.1 DUF945 domain-containing protein -
CEJ55_RS06760 1319231..1319464 - 234 WP_049592654.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.13 Da        Isoelectric Point: 7.3524

>T78938 WP_049592807.1 NZ_CP022393:c1316380-1316003 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T78938 NZ_CP022393:c1316380-1316003 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13733.48 Da        Isoelectric Point: 6.4814

>AT78938 WP_089180163.1 NZ_CP022393:c1316801-1316427 [Escherichia coli]
VSDKLSGITHPDDNHDHPWWGLPCTVRPCFGARLVQEGNHLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLTVYPTPAPATTS

Download         Length: 375 bp

>AT78938 NZ_CP022393:c1316801-1316427 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCACCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCACCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References