Detailed information of TA system TA078866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2797339..2797988
• Replicon: chromosome
• Accession: NZ_CP022298
• Organism: Acinetobacter johnsonii strain IC001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CFH90_RS13745
• Protein ID: WP_126037793.1
• Coordinates: 2797339..2797758 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D0SB20
• Locus tag: CFH90_RS13750
• Protein ID: WP_005400268.1
• Coordinates: 2797758..2797988 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFH90_RS13710	2793220..2793615	-	396	WP_126037780.1	VOC family protein	-
CFH90_RS13715	2794205..2794477	-	273	WP_126037783.1	hypothetical protein	-
CFH90_RS13720	2794585..2795283	-	699	WP_171457130.1	hypothetical protein	-
CFH90_RS13730	2795933..2796139	-	207	WP_126037786.1	hypothetical protein	-
CFH90_RS13735	2796371..2796946	-	576	WP_126037789.1	DUF4126 domain-containing protein	-
CFH90_RS13740	2797065..2797208	-	144	WP_004695201.1	zinc ribbon-containing protein	-
CFH90_RS13745	2797339..2797758	-	420	WP_126037793.1	type II toxin-antitoxin system VapC family toxin	Toxin
CFH90_RS13750	2797758..2797988	-	231	WP_005400268.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CFH90_RS13755	2798093..2798626	-	534	WP_126037796.1	hypothetical protein	-
CFH90_RS13760	2798729..2799070	-	342	WP_126037799.1	hypothetical protein	-
CFH90_RS13765	2799275..2799844	-	570	WP_126037802.1	hypothetical protein	-
CFH90_RS13770	2799942..2802548	-	2607	WP_126037805.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16159.48 Da
• Isoelectric Point: 6.1317

>T78866 WP_126037793.1 NZ_CP022298:c2797758-2797339 [Acinetobacter johnsonii]
MQTQYLLDTNICIYIIQHQPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQQKEKALKVIDELTSMIQVVELDEYVA
DHYAQIRHDLSSKGQIIGANDLWLAAHARANNWVMVTNNEKEFLRVDGLQIENWVTNTL

Nucleotide

• Length: 420 bp

>T78866 NZ_CP022298:c2797758-2797339 [Acinetobacter johnsonii]
ATGCAGACACAATATTTATTGGATACAAATATTTGTATCTACATCATCCAACATCAACCTGAAATTGTCCGTCAGCATTT
TGAAAAACATCTCCCACATCGAAATATTTTAATTTCAGTCATTACTTTGGGGGAGTTGCGTTTTGGTGCAGAGAAAAGTC
AGCAAAAAGAAAAAGCCCTCAAAGTGATAGATGAATTAACCTCAATGATTCAAGTAGTTGAGTTAGATGAATATGTCGCT
GACCACTATGCGCAAATACGTCACGATCTTTCATCCAAGGGGCAGATTATTGGTGCGAATGATTTGTGGCTTGCCGCGCA
TGCACGTGCGAATAATTGGGTGATGGTGACCAATAATGAAAAAGAATTTTTGCGTGTCGATGGATTGCAGATCGAAAATT
GGGTGACTAACACCTTGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9037.30 Da
• Isoelectric Point: 4.7049

>AT78866 WP_005400268.1 NZ_CP022298:c2797988-2797758 [Acinetobacter johnsonii]
MTTAKVFMTGRSQAVRLPKEFRFEGTEVEIFRRGDEVILREKPVTVDRLFKVLAQMPNDFYAEERVDEPPQEREEF

Nucleotide

• Length: 231 bp

>AT78866 NZ_CP022298:c2797988-2797758 [Acinetobacter johnsonii]
ATGACTACCGCAAAAGTTTTTATGACTGGTCGAAGTCAAGCTGTTCGCTTACCCAAAGAATTTCGCTTTGAAGGTACAGA
AGTCGAAATTTTCCGTCGTGGCGATGAAGTGATTCTGCGTGAAAAACCAGTTACCGTAGATCGGTTATTTAAAGTATTAG
CGCAAATGCCGAATGACTTTTATGCAGAAGAAAGAGTGGATGAACCACCACAGGAACGAGAAGAGTTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8XEV0