Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 170732..170988 Replicon chromosome
Accession NZ_CP022279
Organism Escherichia coli strain STEC299

Toxin (Protein)


Gene name hokA Uniprot ID A0A827QNR8
Locus tag CFI09_RS00845 Protein ID WP_001135730.1
Coordinates 170836..170988 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 170732..170786 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFI09_RS00825 165951..166946 - 996 WP_001182669.1 O-acetyltransferase WecH -
CFI09_RS00830 167121..167429 + 309 WP_000980157.1 YsaB family lipoprotein -
CFI09_RS00835 167524..168435 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
CFI09_RS00840 168445..170514 + 2070 WP_001291788.1 glycine--tRNA ligase subunit beta -
- 170732..170786 - 55 - - Antitoxin
CFI09_RS00845 170836..170988 + 153 WP_001135730.1 type I toxin-antitoxin system toxin HokA Toxin
CFI09_RS27735 170965..171036 - 72 WP_212734774.1 hypothetical protein -
CFI09_RS00850 171176..171388 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CFI09_RS00855 171669..171959 - 291 WP_000455798.1 HTH-type transcriptional regulator -
CFI09_RS00860 172393..173103 + 711 WP_000190516.1 DUF3053 domain-containing protein -
CFI09_RS00865 173153..174127 - 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
CFI09_RS00870 174231..174890 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 6025.34 Da        Isoelectric Point: 8.2731

>T78778 WP_001135730.1 NZ_CP022279:170836-170988 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKKENYELAAFLACKLKE

Download         Length: 153 bp

>T78778 NZ_CP022279:170836-170988 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAAAAGGAGAATTATGAGCTGGCCGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT78778 NZ_CP022279:c170786-170732 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827QNR8

Antitoxin

Download structure file

References