Detailed information of TA system TA078337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 166010..166667
• Replicon: plasmid unnamed3
• Accession: NZ_CP022063
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain FDAARGOS_312

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: CEP90_RS26295
• Protein ID: WP_000270043.1
• Coordinates: 166010..166360 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CEP90_RS26300
• Protein ID: WP_000124640.1
• Coordinates: 166365..166667 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP90_RS26255	162472..162969	-	498	WP_000062185.1	hypothetical protein	-
CEP90_RS26260	162972..163460	-	489	WP_001273096.1	DUF1643 domain-containing protein	-
CEP90_RS26265	163557..163913	+	357	WP_020833609.1	hypothetical protein	-
CEP90_RS26270	163922..164392	-	471	WP_001281821.1	hypothetical protein	-
CEP90_RS26275	164385..164756	-	372	WP_020833608.1	hypothetical protein	-
CEP90_RS26280	164764..164958	-	195	WP_000343597.1	hypothetical protein	-
CEP90_RS26290	165299..165847	-	549	WP_001061574.1	transcriptional regulator	-
CEP90_RS26295	166010..166360	+	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEP90_RS26300	166365..166667	+	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
CEP90_RS26305	166695..166988	-	294	WP_020833606.1	chromosome segregation protein ParM	-
CEP90_RS26310	167077..167349	-	273	WP_020833605.1	HU family DNA-binding protein	-
CEP90_RS26315	167407..167934	-	528	WP_020833604.1	thermonuclease family protein	-
CEP90_RS26325	168165..169022	-	858	WP_020833602.1	hypothetical protein	-
CEP90_RS26330	169009..169239	-	231	WP_020833601.1	hypothetical protein	-
CEP90_RS26335	169239..169757	-	519	WP_020833600.1	hypothetical protein	-
CEP90_RS26340	169754..170200	-	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
CEP90_RS26345	170200..170559	-	360	WP_000422768.1	hypothetical protein	-
CEP90_RS26350	170616..171044	-	429	WP_000591074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..173817	173817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T78337 WP_000270043.1 NZ_CP022063:166010-166360 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T78337 NZ_CP022063:166010-166360 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>AT78337 WP_000124640.1 NZ_CP022063:166365-166667 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>AT78337 NZ_CP022063:166365-166667 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9