Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-YafN |
| Location | 2089584..2090106 | Replicon | chromosome |
| Accession | NZ_CP022015 | ||
| Organism | Salmonella enterica subsp. enterica serovar India str. SA20085604 | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A5J1ICX1 |
| Locus tag | LFZ16_RS10620 | Protein ID | WP_000221344.1 |
| Coordinates | 2089584..2089868 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | V1H457 |
| Locus tag | LFZ16_RS10625 | Protein ID | WP_000885424.1 |
| Coordinates | 2089858..2090106 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFZ16_RS10595 (2084588) | 2084588..2085829 | - | 1242 | WP_023212743.1 | MFS transporter | - |
| LFZ16_RS10600 (2085819) | 2085819..2087327 | - | 1509 | WP_023212744.1 | FAD-dependent oxidoreductase | - |
| LFZ16_RS10605 (2087372) | 2087372..2087860 | + | 489 | WP_001293635.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| LFZ16_RS10610 (2088053) | 2088053..2089126 | + | 1074 | WP_023212745.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
| LFZ16_RS10615 (2089184) | 2089184..2089465 | - | 282 | Protein_2087 | RidA family protein | - |
| LFZ16_RS10620 (2089584) | 2089584..2089868 | - | 285 | WP_000221344.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFZ16_RS10625 (2089858) | 2089858..2090106 | - | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LFZ16_RS10630 (2090258) | 2090258..2090377 | + | 120 | Protein_2090 | type II and III secretion system | - |
| LFZ16_RS10635 (2090463) | 2090463..2090795 | + | 333 | WP_223353304.1 | DUF1493 family protein | - |
| LFZ16_RS10640 (2091209) | 2091209..2091535 | - | 327 | WP_223353305.1 | hypothetical protein | - |
| LFZ16_RS10645 (2091577) | 2091577..2092053 | - | 477 | WP_223353306.1 | helix-turn-helix transcriptional regulator | - |
| LFZ16_RS10650 (2092182) | 2092182..2093459 | + | 1278 | WP_223353307.1 | phage/plasmid replication protein, II/X family | - |
| LFZ16_RS10655 (2093502) | 2093502..2093777 | + | 276 | WP_223353308.1 | G5P family DNA-binding protein | - |
| LFZ16_RS10660 (2093795) | 2093795..2094109 | + | 315 | WP_223353309.1 | hypothetical protein | - |
| LFZ16_RS10665 (2094732) | 2094732..2095058 | - | 327 | WP_223353305.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11015.73 Da Isoelectric Point: 10.5388
>T78178 WP_000221344.1 NZ_CP022015:c2089868-2089584 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
Download Length: 285 bp
>T78178 NZ_CP022015:c2089868-2089584 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT78178 WP_000885424.1 NZ_CP022015:c2090106-2089858 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT78178 NZ_CP022015:c2090106-2089858 [Salmonella enterica subsp. enterica serovar India str. SA20085604]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1ICX1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I0WPN5 |