Detailed information of TA system TA078101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 801238..801860
• Replicon: chromosome
• Accession: NZ_CP022010
• Organism: Mergibacter septicus strain 27643-20-I1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CEP45_RS03555
• Protein ID: WP_261920724.1
• Coordinates: 801678..801860 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CEP45_RS03550
• Protein ID: WP_261920725.1
• Coordinates: 801238..801642 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEP45_RS03545 (CEP45_03525)	800375..801088	-	714	WP_265491127.1	hypothetical protein	-
CEP45_RS03550 (CEP45_03530)	801238..801642	-	405	WP_261920725.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CEP45_RS03555 (CEP45_03535)	801678..801860	-	183	WP_261920724.1	type II toxin-antitoxin system HicA family toxin	Toxin
CEP45_RS03560 (CEP45_03540)	802088..803110	-	1023	WP_265491128.1	porphobilinogen synthase	-
CEP45_RS03565 (CEP45_03545)	803213..803998	-	786	WP_261920722.1	Sec-independent protein translocase subunit TatC	-
CEP45_RS03570 (CEP45_03550)	804070..804678	-	609	WP_265491129.1	Sec-independent protein translocase protein TatB	-
CEP45_RS03575 (CEP45_03555)	804682..804915	-	234	WP_265491130.1	Sec-independent protein translocase subunit TatA	-
CEP45_RS03580 (CEP45_03560)	805012..806655	-	1644	WP_265491131.1	ubiquinone biosynthesis regulatory protein kinase UbiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6893.21 Da
• Isoelectric Point: 11.1504

>T78101 WP_261920724.1 NZ_CP022010:c801860-801678 [Mergibacter septicus]
VNSATLMKLIEEDGWFLVSIKGSHHQFKHPIKKGRVTIPHPKKDLHIKTVNSILKQARLK

Nucleotide

• Length: 183 bp

>T78101 NZ_CP022010:c801860-801678 [Mergibacter septicus]
GTGAACAGTGCAACGTTAATGAAACTAATTGAGGAAGATGGCTGGTTTCTTGTATCAATAAAAGGAAGTCATCATCAATT
CAAACACCCTATAAAAAAAGGACGTGTTACTATCCCTCATCCGAAAAAGGATTTACATATAAAAACAGTAAATTCAATCT
TAAAACAAGCAAGGCTAAAATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14862.05 Da
• Isoelectric Point: 4.5389

>AT78101 WP_261920725.1 NZ_CP022010:c801642-801238 [Mergibacter septicus]
MLYPIGIEMGDEKHAFSVIVPDIPGCFSAGDTLEEAFTNAKEAIAFHIAGMLEDGEEIPLPTDLQLHMNNKEYEGFTFSV
VDVDLTHLMGKTEKINITLPSLLLHKIDSFVATHPEYKNRSNFLAKIATEKVLA

Nucleotide

• Length: 405 bp

>AT78101 NZ_CP022010:c801642-801238 [Mergibacter septicus]
ATGTTATATCCAATTGGAATTGAAATGGGTGATGAAAAACACGCTTTTAGTGTTATTGTACCTGATATTCCGGGTTGCTT
TTCTGCAGGCGATACATTGGAAGAAGCCTTTACAAATGCAAAAGAAGCAATAGCTTTTCATATTGCAGGTATGCTTGAGG
ACGGTGAAGAAATCCCATTGCCAACAGACCTACAACTACATATGAATAACAAGGAATATGAAGGATTTACCTTTAGCGTG
GTAGATGTTGATCTAACTCATTTAATGGGAAAAACAGAAAAAATTAATATAACCTTGCCATCATTGCTGCTCCATAAAAT
TGACAGCTTTGTTGCAACTCACCCAGAATATAAAAACCGCAGCAACTTTTTAGCCAAAATCGCCACAGAAAAAGTATTAG
CATAA