Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 462594..463360 Replicon chromosome
Accession NZ_CP021981
Organism Vibrio anguillarum strain 87-9-116

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag CEA93_RS16835 Protein ID WP_013867769.1
Coordinates 462594..463091 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag CEA93_RS16840 Protein ID WP_013867770.1
Coordinates 463088..463360 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEA93_RS16790 459063..459416 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
CEA93_RS16795 459413..459730 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
CEA93_RS16800 459845..459937 + 93 WP_019281220.1 DUF3265 domain-containing protein -
CEA93_RS16805 460025..460231 + 207 WP_013867765.1 DUF1289 domain-containing protein -
CEA93_RS16810 460351..460581 - 231 WP_013867766.1 PAS factor family protein -
CEA93_RS16815 460875..461111 - 237 WP_013867767.1 hypothetical protein -
CEA93_RS16820 461396..461884 + 489 WP_013867768.1 hypothetical protein -
CEA93_RS16825 461875..462006 + 132 Protein_402 DUF3265 domain-containing protein -
CEA93_RS16835 462594..463091 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
CEA93_RS16840 463088..463360 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
CEA93_RS16850 464111..464830 + 720 Protein_405 hypothetical protein -
CEA93_RS16855 464887..465807 - 921 WP_011154643.1 IS5-like element ISVa2 family transposase -
CEA93_RS16860 465912..466199 + 288 WP_157727321.1 potassium channel family protein -
CEA93_RS16865 466225..467193 - 969 WP_076611895.1 IS30-like element ISVa6 family transposase -
CEA93_RS16875 467566..467955 + 390 WP_019280976.1 DUF1090 domain-containing protein -
CEA93_RS16880 467959..468048 + 90 WP_019280977.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 422978..467955 44977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T78052 WP_013867769.1 NZ_CP021981:c463091-462594 [Vibrio anguillarum]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T78052 NZ_CP021981:c463091-462594 [Vibrio anguillarum]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT78052 WP_013867770.1 NZ_CP021981:c463360-463088 [Vibrio anguillarum]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT78052 NZ_CP021981:c463360-463088 [Vibrio anguillarum]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References