Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2466591..2466775 Replicon chromosome
Accession NZ_CP021905
Organism Staphylococcus aureus strain Seattle 1945 isolate G477

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag CD017_RS12730 Protein ID WP_000482647.1
Coordinates 2466668..2466775 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2466591..2466651 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD017_RS12705 2462101..2462268 - 168 Protein_2360 hypothetical protein -
CD017_RS12715 2462499..2464232 - 1734 WP_000486507.1 ABC transporter ATP-binding protein/permease -
CD017_RS12720 2464257..2466020 - 1764 WP_001064828.1 ABC transporter ATP-binding protein/permease -
- 2466591..2466651 + 61 - - Antitoxin
CD017_RS12730 2466668..2466775 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
CD017_RS12735 2466909..2467295 - 387 WP_000779351.1 flippase GtxA -
CD017_RS12740 2467563..2468705 + 1143 WP_001176855.1 glycerate kinase -
CD017_RS12745 2468765..2469424 + 660 WP_000831298.1 membrane protein -
CD017_RS12750 2469606..2470817 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
CD017_RS12755 2470940..2471413 - 474 WP_000456499.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T77843 WP_000482647.1 NZ_CP021905:c2466775-2466668 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T77843 NZ_CP021905:c2466775-2466668 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT77843 NZ_CP021905:2466591-2466651 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References