Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 543223..543893 Replicon plasmid psymA
Accession NZ_CP021813
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO26_RS20920 Protein ID WP_088197815.1
Coordinates 543474..543893 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO26_RS20915 Protein ID WP_088197814.1
Coordinates 543223..543477 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS20895 (CDO26_20900) 539405..540340 + 936 WP_088197812.1 ABC transporter permease -
CDO26_RS20900 (CDO26_20905) 540346..541167 + 822 WP_010967053.1 ABC transporter permease -
CDO26_RS20905 (CDO26_20910) 541164..542078 + 915 WP_088197813.1 ABC transporter ATP-binding protein -
CDO26_RS20910 (CDO26_20915) 542075..543037 + 963 WP_027989026.1 ATP-binding cassette domain-containing protein -
CDO26_RS20915 (CDO26_20920) 543223..543477 + 255 WP_088197814.1 plasmid stabilization protein Antitoxin
CDO26_RS20920 (CDO26_20925) 543474..543893 + 420 WP_088197815.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO26_RS20925 (CDO26_20930) 543862..544290 - 429 WP_153492020.1 GFA family protein -
CDO26_RS20930 (CDO26_20935) 544691..547225 + 2535 WP_088197817.1 PAS domain S-box protein -
CDO26_RS20935 (CDO26_20940) 547253..547615 + 363 WP_088197818.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1454983 1454983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14885.21 Da        Isoelectric Point: 6.4653

>T77500 WP_088197815.1 NZ_CP021813:543474-543893 [Sinorhizobium meliloti]
MIVLDTNVVSEAMKPAPDPAVRSWLNEQVAETLYLASVTLAELLFGIGALPAGRRKKALPEMLDGVLELFGDRVLPFDIG
AARCYAELQVTARAAGKGFPPPDGYIAAIAASRGFIVATRDSRPFEAAGLTVANPWHHR

Download         Length: 420 bp

>T77500 NZ_CP021813:543474-543893 [Sinorhizobium meliloti]
ATGATTGTCCTGGATACGAATGTCGTCTCCGAGGCGATGAAACCGGCCCCCGATCCGGCCGTGCGCTCCTGGTTGAACGA
GCAGGTCGCTGAAACCTTGTATCTGGCCAGTGTGACCTTGGCCGAACTGCTGTTCGGCATCGGTGCGCTGCCGGCCGGTC
GGCGCAAGAAGGCTCTGCCCGAAATGCTTGACGGCGTGCTCGAACTGTTTGGCGATCGCGTATTGCCGTTCGACATTGGA
GCTGCTCGCTGCTATGCCGAGCTTCAGGTGACCGCTCGAGCGGCCGGCAAAGGATTTCCGCCGCCTGACGGATATATTGC
CGCCATTGCCGCCTCCAGGGGATTTATCGTCGCGACCCGCGACAGCAGACCGTTCGAGGCGGCTGGACTTACCGTGGCAA
ATCCTTGGCACCATCGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9439.78 Da        Isoelectric Point: 6.4732

>AT77500 WP_088197814.1 NZ_CP021813:543223-543477 [Sinorhizobium meliloti]
MAILTGRNVPDEVHRALRVRAAMHGRSTEAEVREILESAVKPEPRVRMGDALAELGRRLGLTNDDFAVFDEVRDKAPAQP
MRFE

Download         Length: 255 bp

>AT77500 NZ_CP021813:543223-543477 [Sinorhizobium meliloti]
ATGGCGATCCTGACGGGTCGGAATGTGCCCGATGAAGTGCATCGCGCCTTGCGCGTGAGAGCGGCGATGCACGGCCGCAG
CACCGAGGCGGAAGTCCGGGAGATTTTGGAAAGTGCGGTGAAGCCCGAGCCGCGCGTTCGCATGGGCGATGCCCTGGCCG
AGCTCGGCCGGCGACTGGGGCTGACCAATGACGATTTCGCAGTGTTCGACGAGGTACGTGACAAGGCGCCGGCGCAGCCA
ATGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References