Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 219548..220221 Replicon chromosome
Accession NZ_CP021812
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO26_RS01120 Protein ID WP_010969926.1
Coordinates 219548..219952 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0GA10
Locus tag CDO26_RS01125 Protein ID WP_003536345.1
Coordinates 219949..220221 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS01075 (CDO26_01075) 215112..215252 - 141 WP_010969932.1 hemin uptake protein HemP -
CDO26_RS01080 (CDO26_01080) 215482..215916 + 435 WP_010969931.1 hypothetical protein -
CDO26_RS01085 (CDO26_01085) 215957..216883 + 927 WP_010969930.1 energy transducer TonB -
CDO26_RS01090 (CDO26_01090) 217091..217504 + 414 WP_003536357.1 DUF2325 domain-containing protein -
CDO26_RS01095 (CDO26_01095) 217557..217823 + 267 WP_010969929.1 hypothetical protein -
CDO26_RS01100 (CDO26_01100) 217836..218150 + 315 WP_003536354.1 antibiotic biosynthesis monooxygenase -
CDO26_RS01105 (CDO26_01105) 218265..218525 - 261 WP_010969928.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CDO26_RS01110 (CDO26_01110) 218648..219022 - 375 WP_010969927.1 DUF423 domain-containing protein -
CDO26_RS01115 (CDO26_01115) 219028..219420 - 393 WP_003536349.1 globin -
CDO26_RS01120 (CDO26_01120) 219548..219952 - 405 WP_010969926.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO26_RS01125 (CDO26_01125) 219949..220221 - 273 WP_003536345.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDO26_RS01130 (CDO26_01130) 220358..220918 + 561 WP_010969925.1 TetR/AcrR family transcriptional regulator -
CDO26_RS01135 (CDO26_01135) 220966..221307 + 342 WP_003536339.1 SMR family transporter -
CDO26_RS01140 (CDO26_01140) 221487..222542 + 1056 WP_014529838.1 dipeptidase -
CDO26_RS01145 (CDO26_01145) 222590..224230 + 1641 WP_088196805.1 ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-124)

Antitoxin

(16-54)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14747.98 Da        Isoelectric Point: 5.1974

>T77492 WP_010969926.1 NZ_CP021812:c219952-219548 [Sinorhizobium meliloti]
MNGYLLDTNIISDVIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYALDLTLVTDNIREFSRVRGLSLENWLER

Download         Length: 405 bp

>T77492 NZ_CP021812:c219952-219548 [Sinorhizobium meliloti]
TTGAACGGCTATCTTCTCGATACGAACATCATCAGCGACGTCATTCACAATCCGTTCGGACCGGCTGCGCAACGCATCGA
ACGGATCGGCCCGAAGGAGATTTACACCAGCATCGTCGTCGCGTCCGAGTTGCGGTATGGTTGCGCAAAAAAGGGATCGG
CGAAGTTGCTCGCCAAGGTCGAAAGCTTGCTGGAAATCGTCCCGGTGCTGCCATTGGATATTCCGGCCGACACCCGATAT
GGCAGCATTCGTGCGGAATTGGAGTCTCTGGGGCAGACCATCGGCTCCAACGATCTGTTGATTGCCGCGCATGCATATGC
GCTGGACCTGACGCTGGTGACGGACAATATCCGTGAGTTCAGCCGCGTTCGTGGCCTTAGTCTGGAAAACTGGCTTGAGC
GATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10334.02 Da        Isoelectric Point: 6.3950

>AT77492 WP_003536345.1 NZ_CP021812:c220221-219949 [Sinorhizobium meliloti]
MPVPLPSSRPKEVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPIARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF

Download         Length: 273 bp

>AT77492 NZ_CP021812:c220221-219949 [Sinorhizobium meliloti]
ATGCCCGTCCCGTTGCCGTCATCGCGACCTAAAGAAGTAAAGCTGTTCCGCAATAACCGCAGCCAGGCAGTCCGTATTCC
TGCGGAGTTCGAGTTGCCTGGAGACCGTGTGTTGATCCGTCGCGAAGGAACGAGACTCATTATCGAACCGATAGCCAGGC
CAGCCGATATCGTGGAGCTTCTCGCGGAGTGGAAGAAGGAAGCTCCCCTCGGACCTGAAGACCGGTTCCCGGATGTTGAG
GATATACCCGCCCGGCCGGAGAAAATCTTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB H0GA10

References