Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 102458..103992 Replicon chromosome
Accession NZ_CP021768
Organism Stenotrophomonas sp. WZN-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CCR98_RS00435 Protein ID WP_087921100.1
Coordinates 102458..103783 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CCR98_RS00440 Protein ID WP_087924110.1
Coordinates 103786..103992 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCR98_RS00420 97815..99449 - 1635 WP_087921098.1 TldD/PmbA family protein -
CCR98_RS00425 99480..101111 - 1632 WP_198361046.1 TldD/PmbA family protein -
CCR98_RS00430 101843..102457 + 615 WP_087921099.1 DUF938 domain-containing protein -
CCR98_RS00435 102458..103783 - 1326 WP_087921100.1 type II toxin-antitoxin system HipA family toxin Toxin
CCR98_RS00440 103786..103992 - 207 WP_087924110.1 helix-turn-helix transcriptional regulator Antitoxin
CCR98_RS00445 104326..108012 - 3687 WP_087921101.1 indolepyruvate ferredoxin oxidoreductase family protein -
CCR98_RS00450 108182..108817 + 636 WP_087921102.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-53)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49351.10 Da        Isoelectric Point: 6.3718

>T77352 WP_087921100.1 NZ_CP021768:c103783-102458 [Stenotrophomonas sp. WZN-1]
MSELTIWMNGVEVAKWQQNWNSSPRLTYTQNWLESGSPRPLSLSLPLLPLGESHRGQKVVDYFDNLLPDNSEIRSRLRDR
FSTRSAGTFDLLEAIGRDCVGAVQLLPDAATPNDLQSIQFQPLDEGEVAAILRGVTAPALPGSRHHPSDEFRISIAGAQE
KTGLLLHEGQWCIPIGSTPSTHIFKLPLGLVGNMRADMHQSVENEWLCMHLLSACGIPVAETQMGRFQDQRALIVERFDR
RLSADRRWWLRLPQEDMCQVFGLPAAKKYESDGGPGIVAIMDLLRQSEHSEDRATFFKTQILFWMLAATDGHAKNFSVHI
EAGGRFRLTPIYDVISVYPILGRGPGQLEPRDAKLAMSINGRNRHRRLLDIRRRHWNETARACGVSDGAEPWIETLLETV
EPAIEQVTRQLPDDFPSNVSGPIFQGLRDAAARLSSMAPDA

Download         Length: 1326 bp

>T77352 NZ_CP021768:c103783-102458 [Stenotrophomonas sp. WZN-1]
ATGAGTGAGCTAACGATCTGGATGAATGGTGTAGAGGTAGCGAAATGGCAGCAGAACTGGAACAGCTCTCCGCGCCTTAC
CTATACCCAGAACTGGCTTGAGTCTGGTTCGCCACGCCCTCTTTCCCTCTCACTCCCATTGCTGCCACTTGGTGAAAGTC
ACCGTGGACAGAAAGTTGTCGACTACTTCGACAACCTTCTTCCTGACAATAGCGAGATCAGAAGCAGGCTACGTGATCGC
TTTTCAACCCGCTCAGCGGGAACCTTTGACCTTCTTGAGGCCATCGGTCGGGATTGCGTTGGCGCAGTGCAGCTGCTACC
CGATGCAGCCACACCCAACGATCTGCAGAGCATCCAATTCCAACCATTGGATGAGGGCGAAGTTGCGGCCATCCTGCGAG
GAGTTACTGCACCCGCCCTGCCAGGATCAAGACACCATCCGAGTGACGAGTTTCGAATCTCTATCGCCGGTGCGCAGGAG
AAGACAGGGCTACTTCTGCACGAGGGTCAGTGGTGCATTCCAATCGGCAGCACGCCCTCTACTCATATCTTCAAGTTGCC
CCTAGGCCTGGTCGGTAACATGAGGGCAGACATGCACCAGTCAGTCGAGAACGAGTGGCTGTGCATGCATCTGCTTTCCG
CCTGCGGAATTCCCGTTGCAGAGACGCAGATGGGACGTTTCCAGGACCAACGCGCGCTCATTGTCGAGCGATTCGACCGC
CGTCTTTCTGCGGACCGCCGATGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTTGGTCTGCCCGCTGCCAA
GAAATATGAATCCGATGGTGGCCCAGGGATCGTGGCCATCATGGATCTGCTTCGACAATCCGAGCATTCCGAGGATCGCG
CGACCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGCCATGCCAAGAACTTCAGCGTTCACATT
GAAGCTGGCGGCCGCTTCAGATTGACTCCTATCTATGACGTGATTTCGGTCTACCCCATTCTCGGCCGCGGCCCCGGCCA
ACTGGAGCCTCGTGATGCGAAGCTCGCAATGAGTATCAATGGACGGAATCGACACCGCAGGCTGCTGGACATTCGACGAC
GGCATTGGAACGAAACAGCTCGCGCCTGCGGTGTAAGCGATGGCGCAGAACCATGGATCGAGACACTGCTGGAGACCGTA
GAACCTGCCATCGAACAGGTCACGCGTCAGCTCCCGGATGATTTCCCTTCCAACGTGTCCGGACCTATTTTCCAGGGACT
GCGTGATGCGGCGGCACGCCTTTCCAGCATGGCACCGGACGCCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7602.69 Da        Isoelectric Point: 7.0107

>AT77352 WP_087924110.1 NZ_CP021768:c103992-103786 [Stenotrophomonas sp. WZN-1]
MKAFRKQAGLTQTELGKQLGISRQAVTALEHEPETASFGRLMKVWAVLGIEVTLQQGAERSNTQDMEW

Download         Length: 207 bp

>AT77352 NZ_CP021768:c103992-103786 [Stenotrophomonas sp. WZN-1]
ATGAAAGCGTTTCGCAAGCAGGCGGGCCTGACGCAAACAGAACTTGGCAAACAACTTGGTATCAGCCGCCAAGCAGTGAC
AGCTCTCGAGCACGAACCAGAAACAGCTTCGTTTGGGCGCCTGATGAAGGTGTGGGCGGTACTAGGGATCGAGGTGACTC
TACAACAGGGGGCGGAGCGCTCGAACACTCAAGATATGGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References