Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4057027..4057858 Replicon chromosome
Accession NZ_CP021689
Organism Escherichia coli strain AR_0058

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AM437_RS21325 Protein ID WP_000854815.1
Coordinates 4057484..4057858 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AM437_RS21320 Protein ID WP_001280918.1
Coordinates 4057027..4057395 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM437_RS21270 4052433..4052783 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
AM437_RS21275 4052780..4053205 - 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
AM437_RS21280 4053311..4053721 + 411 WP_000846703.1 hypothetical protein -
AM437_RS21290 4053942..4054760 + 819 WP_001542275.1 DUF945 domain-containing protein -
AM437_RS21295 4054760..4055005 + 246 WP_001164966.1 hypothetical protein -
AM437_RS21300 4055099..4055572 + 474 WP_001542276.1 antirestriction protein -
AM437_RS21305 4055588..4056064 + 477 WP_001186200.1 RadC family protein -
AM437_RS21310 4056127..4056348 + 222 WP_000692345.1 DUF987 domain-containing protein -
AM437_RS21315 4056367..4057011 + 645 WP_000086752.1 hypothetical protein -
AM437_RS21320 4057027..4057395 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM437_RS21325 4057484..4057858 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM437_RS21330 4057855..4058049 + 195 WP_000988600.1 hypothetical protein -
AM437_RS27050 4058062..4058175 + 114 WP_001161660.1 DUF957 domain-containing protein -
AM437_RS21335 4058464..4058610 - 147 Protein_3901 transposase domain-containing protein -
AM437_RS21340 4058664..4058846 + 183 WP_001296208.1 hypothetical protein -
AM437_RS21345 4058947..4059276 - 330 WP_000450409.1 DUF496 family protein -
AM437_RS21350 4059448..4060506 - 1059 WP_001200889.1 FUSC family protein -
AM437_RS21355 4060704..4061177 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
AM437_RS21360 4061296..4062462 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T77007 WP_000854815.1 NZ_CP021689:4057484-4057858 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T77007 NZ_CP021689:4057484-4057858 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT77007 WP_001280918.1 NZ_CP021689:4057027-4057395 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT77007 NZ_CP021689:4057027-4057395 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References