Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 3011545..3012153 Replicon chromosome
Accession NZ_CP021641
Organism Alcaligenes faecalis strain JQ135

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AFA_RS13890 Protein ID WP_094197431.1
Coordinates 3011545..3011835 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag AFA_RS13895 Protein ID WP_094197432.1
Coordinates 3011848..3012153 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFA_RS13870 3006821..3007408 - 588 WP_094197428.1 XRE family transcriptional regulator -
AFA_RS13875 3007548..3008510 + 963 WP_094198411.1 ornithine cyclodeaminase family protein -
AFA_RS13880 3008547..3009839 + 1293 WP_094197429.1 MHS family MFS transporter -
AFA_RS13885 3010107..3011495 + 1389 WP_164461461.1 ATP-dependent RNA helicase DbpA -
AFA_RS13890 3011545..3011835 + 291 WP_094197431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFA_RS13895 3011848..3012153 + 306 WP_094197432.1 putative addiction module antidote protein Antitoxin
AFA_RS13900 3012243..3013199 - 957 WP_094197433.1 LysR family transcriptional regulator -
AFA_RS13905 3013584..3014942 + 1359 WP_094197434.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AFA_RS13910 3014939..3015487 + 549 WP_094197435.1 3-phenylpropionate/cinnamic acid dioxygenase subunit beta -
AFA_RS13915 3015516..3015836 + 321 WP_094198412.1 bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit -
AFA_RS13920 3015833..3016648 + 816 WP_094197436.1 3-(cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10969.39 Da        Isoelectric Point: 7.2772

>T76870 WP_094197431.1 NZ_CP021641:3011545-3011835 [Alcaligenes faecalis]
MKTIHTTDTFDHWFSGLRDKQAARRIQVRIDRAEDGNFGDCESVGEGVSEMRIHYGPGYRVYFVQRELEIVILLAGGNKS
TQNKDIKTALEIARQL

Download         Length: 291 bp

>T76870 NZ_CP021641:3011545-3011835 [Alcaligenes faecalis]
ATGAAGACTATCCACACCACCGATACCTTCGATCACTGGTTTAGCGGTCTGCGCGACAAGCAGGCCGCCAGACGAATTCA
GGTTCGTATTGACCGAGCAGAAGATGGCAACTTTGGAGACTGTGAATCGGTCGGCGAAGGAGTTTCCGAGATGCGTATTC
ACTACGGACCTGGCTACCGTGTGTACTTTGTACAACGTGAACTGGAGATCGTGATCTTATTGGCGGGTGGCAATAAATCT
ACCCAGAATAAAGATATTAAAACTGCGCTGGAAATCGCGCGGCAACTATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10913.57 Da        Isoelectric Point: 6.7173

>AT76870 WP_094197432.1 NZ_CP021641:3011848-3012153 [Alcaligenes faecalis]
MGTIKLRKWDSAEHLQTEEDMVLYLEACMEEAGNDAAFIAKALGNIARAKGMSQLAKETGLGRESLYKALSGEGNPSFGT
ILKVMHALGIKLQPQLAPHNS

Download         Length: 306 bp

>AT76870 NZ_CP021641:3011848-3012153 [Alcaligenes faecalis]
ATGGGAACCATCAAATTACGCAAATGGGATAGTGCCGAACACCTCCAAACCGAGGAAGACATGGTGCTATACCTAGAAGC
CTGCATGGAGGAAGCTGGCAACGATGCCGCTTTCATTGCAAAAGCCTTGGGCAATATTGCTCGCGCCAAGGGCATGAGCC
AGTTGGCTAAAGAAACGGGCTTGGGACGTGAAAGCCTGTACAAAGCCCTGTCAGGCGAAGGCAATCCAAGCTTTGGCACC
ATTCTAAAAGTCATGCACGCCTTGGGAATCAAACTGCAACCACAGCTTGCTCCTCACAACTCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References