Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1275962..1276528 Replicon chromosome
Accession NZ_CP021557
Organism Bifidobacterium breve strain 180W83

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag BB180W83_RS05755 Protein ID WP_014483710.1
Coordinates 1276235..1276528 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag BB180W83_RS05750 Protein ID WP_014483711.1
Coordinates 1275962..1276231 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB180W83_RS05725 1271712..1272407 - 696 WP_003829410.1 response regulator transcription factor -
BB180W83_RS05730 1272533..1273048 + 516 WP_013140733.1 hypothetical protein -
BB180W83_RS05735 1273045..1273935 + 891 WP_016462927.1 hypothetical protein -
BB180W83_RS05740 1273932..1274612 + 681 WP_016462926.1 ABC transporter ATP-binding protein -
BB180W83_RS05745 1274609..1275777 + 1169 Protein_1085 ABC transporter permease -
BB180W83_RS05750 1275962..1276231 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BB180W83_RS05755 1276235..1276528 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
BB180W83_RS05765 1277197..1277748 + 552 WP_015438834.1 RNA polymerase sigma factor -
BB180W83_RS05770 1277782..1278609 + 828 WP_015438835.1 hypothetical protein -
BB180W83_RS05775 1278741..1279367 + 627 WP_015438836.1 hypothetical protein -
BB180W83_RS05780 1279364..1280146 + 783 WP_106630953.1 murein hydrolase transporter LrgB -
BB180W83_RS05785 1280198..1281073 + 876 WP_016462922.1 ABC transporter ATP-binding protein -
BB180W83_RS05790 1281128..1281526 + 399 WP_016462921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1269867..1288254 18387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T76862 WP_014483710.1 NZ_CP021557:1276235-1276528 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T76862 NZ_CP021557:1276235-1276528 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT76862 WP_014483711.1 NZ_CP021557:1275962-1276231 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT76862 NZ_CP021557:1275962-1276231 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References