Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1527539..1527735 Replicon chromosome
Accession NZ_CP021447
Organism Clostridioides difficile strain DSM 104451

Toxin (Protein)


Gene name CD1418.2 Uniprot ID Q18BT8
Locus tag CDIF104451_RS07395 Protein ID WP_009902496.1
Coordinates 1527539..1527691 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 1527635..1527735 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104451_RS07375 (1523080) 1523080..1523628 - 549 WP_011861206.1 DUF308 domain-containing protein -
CDIF104451_RS07380 (1523780) 1523780..1524208 + 429 WP_003429356.1 DMT family transporter -
CDIF104451_RS07385 (1524275) 1524275..1524943 + 669 WP_003429358.1 diphthine--ammonia ligase -
CDIF104451_RS07390 (1525061) 1525061..1526416 - 1356 WP_003438549.1 MATE family efflux transporter -
CDIF104451_RS07395 (1527539) 1527539..1527691 + 153 WP_009902496.1 hypothetical protein Toxin
- (1527635) 1527635..1527735 - 101 NuclAT_10 - Antitoxin
- (1527635) 1527635..1527735 - 101 NuclAT_6 - Antitoxin
- (1527635) 1527635..1527735 - 101 NuclAT_6 - Antitoxin
CDIF104451_RS07400 (1529118) 1529118..1530851 - 1734 WP_021363452.1 sensor domain-containing diguanylate cyclase -
CDIF104451_RS07405 (1531091) 1531091..1531936 - 846 WP_021423340.1 c-di-GMP diguanylate cyclase DccA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5742.81 Da        Isoelectric Point: 10.9178

>T76655 WP_009902496.1 NZ_CP021447:1527539-1527691 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Download         Length: 153 bp

>T76655 NZ_CP021447:1527539-1527691 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTGTACTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAAATAGTAAATTGTTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAAAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT76655 NZ_CP021447:c1527735-1527635 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069ACY9

Antitoxin

Download structure file

References