Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2830582..2832146 Replicon chromosome
Accession NZ_CP021377
Organism Oceanisphaera profunda strain SM1222

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CBP31_RS12525 Protein ID WP_087037789.1
Coordinates 2830582..2831895 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CBP31_RS12530 Protein ID WP_087037791.1
Coordinates 2831895..2832146 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBP31_RS12510 2826118..2829036 - 2919 WP_087037783.1 DEAD/DEAH box helicase family protein -
CBP31_RS12515 2829033..2829635 - 603 WP_087037785.1 class I SAM-dependent methyltransferase -
CBP31_RS12520 2829792..2830277 + 486 WP_087037787.1 nucleoside deaminase -
CBP31_RS12525 2830582..2831895 - 1314 WP_087037789.1 type II toxin-antitoxin system HipA family toxin Toxin
CBP31_RS12530 2831895..2832146 - 252 WP_087037791.1 helix-turn-helix domain-containing protein Antitoxin
CBP31_RS12535 2832826..2833947 - 1122 WP_087038750.1 flagellar assembly protein T N-terminal domain-containing protein -
CBP31_RS12540 2834311..2835060 + 750 WP_087037793.1 hypothetical protein -
CBP31_RS12545 2835074..2835454 + 381 WP_087038753.1 LPP20 family lipoprotein -
CBP31_RS12555 2836305..2836718 - 414 WP_087037797.1 flagellar protein FlgN -
CBP31_RS12560 2836720..2837040 - 321 WP_087037799.1 flagellar biosynthesis anti-sigma factor FlgM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48554.47 Da        Isoelectric Point: 7.8881

>T76555 WP_087037789.1 NZ_CP021377:c2831895-2830582 [Oceanisphaera profunda]
MAQLTIAMNGYQVGTLYRSSSGTHEFWYHQDWLDMPGSRPISLSLPLGKQRFKGEEVYNFFDNLLPDKMQTRQRIVARHQ
AASSQPFDLLAKIGMDSVGALQIYPASQQPEGVRSIHCKKLTQSALLNILQGYQSNAPLGMISGEEDFRISIAGAQEKTA
LLKQNENWYLPLGSTPTTHIIKLPIGTIQSHSHTIDLSTSVENELVCLRLAGALGLEVAAADILDVRGFRALSVARFDRR
RSSDGQWIMRLPQEDFCQVLGVSPGLKYESDGGPNIVKIMSYLLGSAQPEQDRATFMLAQVVFWLLAATDGHAKNFSVFL
LPNGAFRLTPLYDILSAYPVMGGSGLSERKIKMAMALQGSSGRHYQWYNLFPRHFLTTARAAGFDETAMQTILDDVRDRV
PTAINSVRQSLPENFPADISEVIFSGVEKRAKRLDQN

Download         Length: 1314 bp

>T76555 NZ_CP021377:c2831895-2830582 [Oceanisphaera profunda]
ATGGCACAGCTAACTATCGCCATGAATGGCTACCAAGTAGGCACGCTATATCGATCATCATCTGGTACTCATGAGTTTTG
GTACCATCAAGACTGGCTCGATATGCCCGGCTCTCGCCCCATTTCTCTATCCCTACCATTAGGCAAACAACGCTTCAAAG
GTGAAGAGGTATACAATTTTTTTGATAACCTATTACCCGACAAAATGCAGACTCGACAGCGCATTGTCGCTCGTCATCAG
GCAGCTTCAAGTCAGCCCTTTGATCTATTAGCCAAAATTGGGATGGATAGCGTGGGGGCTCTACAGATCTACCCTGCCAG
TCAGCAACCAGAAGGGGTTAGAAGCATTCATTGTAAGAAGTTAACTCAATCGGCGCTGCTGAATATCTTGCAAGGTTATC
AAAGCAATGCACCATTGGGGATGATTAGCGGTGAAGAAGACTTTCGAATTTCGATTGCCGGCGCACAAGAAAAAACTGCG
CTACTCAAACAAAACGAAAATTGGTATCTACCGCTAGGCAGTACACCCACCACACACATTATCAAGTTACCGATAGGTAC
CATCCAAAGTCATTCTCATACCATTGATTTAAGTACTAGCGTCGAAAATGAATTGGTTTGCTTACGCTTAGCCGGTGCAC
TTGGTTTGGAAGTAGCAGCCGCGGATATTCTTGACGTGCGAGGCTTTCGAGCATTGTCCGTGGCCCGCTTTGACCGGCGA
CGATCATCTGACGGTCAATGGATTATGCGCTTACCACAAGAAGACTTTTGTCAGGTTCTAGGCGTATCACCCGGCCTTAA
ATACGAAAGTGATGGAGGCCCAAATATTGTCAAGATTATGAGTTACCTATTGGGCTCAGCTCAACCAGAACAAGATAGAG
CAACCTTCATGCTAGCCCAAGTCGTATTCTGGCTATTAGCAGCAACGGATGGACACGCCAAAAACTTTTCAGTTTTTTTA
CTACCAAATGGGGCCTTCAGACTCACACCACTCTATGACATTCTTTCGGCCTACCCAGTTATGGGTGGCTCGGGGCTCTC
GGAGCGAAAAATCAAAATGGCCATGGCCCTACAAGGATCATCTGGCCGCCATTATCAATGGTATAACCTTTTTCCTCGCC
ACTTTCTAACCACTGCCCGTGCGGCCGGATTTGATGAAACAGCCATGCAAACGATTTTAGATGACGTTAGAGACCGAGTT
CCAACGGCTATCAATAGCGTCAGACAGTCGTTACCTGAAAATTTTCCTGCTGATATAAGTGAAGTCATTTTCTCCGGTGT
AGAAAAACGAGCAAAGCGGCTAGACCAAAACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9474.63 Da        Isoelectric Point: 7.2040

>AT76555 WP_087037791.1 NZ_CP021377:c2832146-2831895 [Oceanisphaera profunda]
MKVTSAHQLSHVLQDQRKQQGQSQTLVARKVGLRQDTVSKFENTPDGTRLDTLFKLLSALDLELEVKPRGSAPNTTEQWQ
EEW

Download         Length: 252 bp

>AT76555 NZ_CP021377:c2832146-2831895 [Oceanisphaera profunda]
ATGAAAGTAACTTCTGCCCATCAACTCAGCCATGTATTACAAGATCAGCGTAAACAACAAGGTCAATCACAGACCCTAGT
GGCTCGCAAGGTTGGGCTGCGCCAAGATACCGTTTCAAAATTCGAAAACACGCCCGACGGTACTCGCCTCGATACCCTGT
TCAAATTGCTTTCGGCATTGGATTTAGAGCTAGAAGTTAAGCCGCGTGGCAGTGCTCCTAATACTACTGAGCAATGGCAG
GAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References