Detailed information of TA system TA076446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1604013..1604692
• Replicon: chromosome
• Accession: NZ_CP021326
• Organism: Acinetobacter baumannii strain XH386

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: CBL09_RS07725
• Protein ID: WP_000838146.1
• Coordinates: 1604013..1604195 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: CBL09_RS07730
• Protein ID: WP_000966688.1
• Coordinates: 1604288..1604692 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBL09_RS07685	1599377..1599745	+	369	WP_038340144.1	hypothetical protein	-
CBL09_RS07690	1599747..1600145	+	399	WP_038340137.1	hypothetical protein	-
CBL09_RS07695	1600147..1600365	+	219	WP_038340131.1	hypothetical protein	-
CBL09_RS07700	1600424..1600777	+	354	WP_000064601.1	hypothetical protein	-
CBL09_RS07705	1600777..1602132	+	1356	WP_047938233.1	hypothetical protein	-
CBL09_RS07710	1602185..1603102	+	918	WP_000094250.1	hypothetical protein	-
CBL09_RS07715	1603172..1603687	+	516	WP_047938234.1	hypothetical protein	-
CBL09_RS07725	1604013..1604195	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
CBL09_RS07730	1604288..1604692	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CBL09_RS07735	1604791..1605309	+	519	WP_004793706.1	DUF4468 domain-containing protein	-
CBL09_RS07740	1605374..1605874	+	501	WP_004793705.1	hypothetical protein	-
CBL09_RS20855	1605997..1606155	+	159	WP_004793704.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1572383..1624543	52160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T76446 WP_000838146.1 NZ_CP021326:1604013-1604195 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T76446 NZ_CP021326:1604013-1604195 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT76446 WP_000966688.1 NZ_CP021326:1604288-1604692 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT76446 NZ_CP021326:1604288-1604692 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6