76386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2651924..2653167 Replicon chromosome
Accession NZ_CP021279
Organism Legionella pneumophila subsp. fraseri strain F-4198

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S6EXA8
Locus tag CA927_RS11875 Protein ID WP_027227417.1
Coordinates 2652229..2653167 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S6EX97
Locus tag CA927_RS11870 Protein ID WP_027227416.1
Coordinates 2651924..2652232 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA927_RS11835 2647273..2648133 + 861 WP_027227410.1 DUF2608 domain-containing protein -
CA927_RS11840 2648485..2648749 - 265 Protein_2295 hypothetical protein -
CA927_RS11845 2648797..2649108 - 312 WP_027227411.1 cupin -
CA927_RS11850 2649124..2649372 - 249 WP_031301595.1 hypothetical protein -
CA927_RS11855 2649679..2650152 + 474 WP_027227413.1 hypothetical protein -
CA927_RS11860 2650342..2651259 + 918 WP_027227414.1 LysR family transcriptional regulator -
CA927_RS11865 2651700..2651927 + 228 WP_027227415.1 helix-turn-helix transcriptional regulator -
CA927_RS11870 2651924..2652232 + 309 WP_027227416.1 HipA N-terminal domain-containing protein Antitoxin
CA927_RS11875 2652229..2653167 + 939 WP_027227417.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA927_RS11880 2653461..2654624 + 1164 WP_027227418.1 hypothetical protein -
CA927_RS11885 2654616..2655803 - 1188 WP_027227419.1 fatty acid desaturase -
CA927_RS11890 2655928..2656095 - 168 WP_011214444.1 DUF3309 domain-containing protein -
CA927_RS11895 2656694..2657050 + 357 WP_063720028.1 hypothetical protein -
CA927_RS11900 2657091..2657375 - 285 Protein_2307 hypothetical protein -
CA927_RS11905 2657419..2658060 - 642 WP_027227422.1 RsmD family RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36142.94 Da        Isoelectric Point: 9.5859

>T76386 WP_027227417.1 NZ_CP021279:2652229-2653167 [Legionella pneumophila subsp. fraseri]
MKRCPITYERISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNRKLALEDFAQLSGEDRHTKYKS
SMEKVIAVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALSLKG
KKNNLTKSDFLKYFAIEKLGLNQKVIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKRLNFFD

Download         Length: 939 bp

>T76386 NZ_CP021279:2652229-2653167 [Legionella pneumophila subsp. fraseri]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCGGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAGAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGCAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGTCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTCGCCATTGAAAAATTAGGATTAAATCAGAAAGTCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAAATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11611.39 Da        Isoelectric Point: 4.5556

>AT76386 WP_027227416.1 NZ_CP021279:2651924-2652232 [Legionella pneumophila subsp. fraseri]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYQGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLVIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT76386 NZ_CP021279:2651924-2652232 [Legionella pneumophila subsp. fraseri]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCAGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAAATTGATAGAAATGAC
TATTTTGGTCAATTGGTAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6EXA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6EX97

References