76380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2769807..2771050 Replicon chromosome
Accession NZ_CP021274
Organism Legionella pneumophila strain D-4040

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CA938_RS12655 Protein ID WP_106195130.1
Coordinates 2770112..2771050 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CA938_RS12650 Protein ID WP_106195127.1
Coordinates 2769807..2770115 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA938_RS12625 2764869..2766380 + 1512 WP_106195112.1 Fic family protein -
CA938_RS12630 2766606..2767031 - 426 WP_106195115.1 hypothetical protein -
CA938_RS12635 2767316..2768905 - 1590 WP_106195118.1 Fic family protein -
CA938_RS12640 2769136..2769345 + 210 WP_106195121.1 hypothetical protein -
CA938_RS12645 2769583..2769810 + 228 WP_106195124.1 helix-turn-helix transcriptional regulator -
CA938_RS12650 2769807..2770115 + 309 WP_106195127.1 HipA N-terminal domain-containing protein Antitoxin
CA938_RS12655 2770112..2771050 + 939 WP_106195130.1 lpg2370 family Dot/Icm T4SS effector Toxin
CA938_RS12660 2771047..2772280 - 1234 Protein_2451 integrase family protein -
CA938_RS12665 2772744..2773424 + 681 WP_062728057.1 hydrolase -
CA938_RS12670 2773495..2775336 + 1842 WP_106184168.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lpg2370 2761468..2773424 11956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36152.88 Da        Isoelectric Point: 9.1475

>T76380 WP_106195130.1 NZ_CP021274:2770112-2771050 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQNVIDGIVQEFHQVIPKWQELIDFSFLSQEMQEKYLELLDQRCKRFNFFD

Download         Length: 939 bp

>T76380 NZ_CP021274:2770112-2771050 [Legionella pneumophila]
ATGAAACGCTGCCCCATTACTTATGAAAAAATCAGTGACCAGGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAACGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTCCAAAAGAAACTAAGTGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATTGTGGATCAAAATGGC
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTGACCTACTTCATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAGTCATACAGCAGTTTTGTACATTCCCAAAAATTGAATTCGTAAAATTATTTAAGCTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCCTGATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCATATGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCTTTGCCTCTGAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGATTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTCGATCAGCGATGCAAGCGATTCAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11582.43 Da        Isoelectric Point: 4.5556

>AT76380 WP_106195127.1 NZ_CP021274:2769807-2770115 [Legionella pneumophila]
MRKAYVSVNGIKAGTLEELQGGKYQFTYFDDYLGAPVSLTMPLTNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT76380 NZ_CP021274:2769807-2770115 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTGAATGGCATTAAGGCTGGAACATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCTGGGCGCGCCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAC
TATTTTGGCCAATTGATAATAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References