Detailed information of TA system TA076363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 2323371..2323911
• Replicon: chromosome
• Accession: NZ_CP021266
• Organism: Legionella pneumophila subsp. pneumophila strain Knoxville

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: CA925_RS10575
• Protein ID: WP_014844324.1
• Coordinates: 2323615..2323911 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: CA925_RS10570
• Protein ID: WP_027224835.1
• Coordinates: 2323371..2323625 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA925_RS10545	2318538..2319029	-	492	WP_016356972.1	hypothetical protein	-
CA925_RS10550	2319040..2319858	-	819	WP_014326980.1	Dam family site-specific DNA-(adenine-N6)-methyltransferase	-
CA925_RS10555	2320444..2321619	-	1176	WP_027224832.1	ISL3 family transposase	-
CA925_RS10560	2321774..2322352	+	579	WP_027224833.1	hypothetical protein	-
CA925_RS10565	2322457..2323023	+	567	WP_027224834.1	hypothetical protein	-
CA925_RS10570	2323371..2323625	+	255	WP_027224835.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CA925_RS10575	2323615..2323911	+	297	WP_014844324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA925_RS10585	2324372..2325386	-	1015	Protein_2046	transposase	-
CA925_RS10590	2325649..2325858	+	210	WP_010947832.1	cold-shock protein	-
CA925_RS10595	2326098..2327504	+	1407	WP_014844326.1	ATP-dependent RNA helicase DbpA	-
CA925_RS10600	2327661..2328572	+	912	WP_014844327.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2320444..2321619	1175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11582.28 Da
• Isoelectric Point: 7.2728

>T76363 WP_014844324.1 NZ_CP021266:2323615-2323911 [Legionella pneumophila subsp. pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Nucleotide

• Length: 297 bp

>T76363 NZ_CP021266:2323615-2323911 [Legionella pneumophila subsp. pneumophila]
ATGTCAAATAAAACATATCGTCTTTACCCAAAAGCGGTAGAAGATCTTGAGTCCATCTATTTATATAGCACAAATGAGTT
TGGTATCAAACGAACAGAGGATTATATTTTAGCTATAGATTTAAGTTTTCAGCGCCTTGCAGATGATCCCTTAATTGCTC
GAAAATGTGATTATATTCGTCCAGAATTACGCGCATTTAATGTTGGCTCTCACATTATTTTTTTCAAAACTACCGATTAC
GGCATTTCTGTTATTCGAGTGTTGCATCAATCTATGGATTTTAATAGACATCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9786.14 Da
• Isoelectric Point: 9.9613

>AT76363 WP_027224835.1 NZ_CP021266:2323371-2323625 [Legionella pneumophila subsp. pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Nucleotide

• Length: 255 bp

>AT76363 NZ_CP021266:2323371-2323625 [Legionella pneumophila subsp. pneumophila]
ATGACCCGTACAATGACTGTTGATTTGGGTAATGAACTTCGTAATTACGTGGAATCACTTGTACGCTCAGGGGATTATAG
AAGTAATAGCGAAGTATTAAGAGAGTCGTTGCGTTTACTTCGTGAAAAACAAGCTGAATCAAAACTAGAGCAGTTGCGTC
ACCTTATAGATGAAGGGGCAGCTAGCGGGAAGCCTGAAACATGGGATGCACATGATTTTCTTAAGAAAATGAAGAAAAAA
TCCCATGTCAAATAA