Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6007248..6008841 Replicon chromosome
Accession NZ_CP021108
Organism Bordetella genomosp. 8 strain AU19157

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CAL12_RS27175 Protein ID WP_086067458.1
Coordinates 6007501..6008841 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CAL12_RS27170 Protein ID WP_086067457.1
Coordinates 6007248..6007499 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAL12_RS27145 6002987..6003298 - 312 WP_086067453.1 (2Fe-2S)-binding protein -
CAL12_RS27150 6003295..6004089 - 795 WP_086067454.1 ABC transporter permease -
CAL12_RS27155 6004093..6004953 - 861 WP_086067455.1 ABC transporter permease -
CAL12_RS27160 6004950..6006026 - 1077 WP_086067456.1 ABC transporter ATP-binding protein -
CAL12_RS27165 6006265..6007107 + 843 WP_086068146.1 IclR family transcriptional regulator -
CAL12_RS27170 6007248..6007499 + 252 WP_086067457.1 helix-turn-helix domain-containing protein Antitoxin
CAL12_RS27175 6007501..6008841 + 1341 WP_086067458.1 type II toxin-antitoxin system HipA family toxin Toxin
CAL12_RS27180 6008871..6009740 - 870 WP_198298336.1 LysR family transcriptional regulator -
CAL12_RS27190 6009897..6010892 + 996 WP_157793142.1 tripartite tricarboxylate transporter substrate binding protein -
CAL12_RS27195 6010889..6012280 + 1392 WP_157793143.1 MmgE/PrpD family protein -
CAL12_RS27200 6012508..6013482 + 975 WP_086067461.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-65)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49022.05 Da        Isoelectric Point: 7.2254

>T75991 WP_086067458.1 NZ_CP021108:6007501-6008841 [Bordetella genomosp. 8]
MARKPLQLNIWMNGSAVGAWRNEPGGSSLTYSEAWINDPGGRPLSLSLPFRLGNTPYKGAIVDDFFDNLLPDSDVIRRRL
AQHHRADSAAPFDLLAVLGRDCVGAIQLLPPHEVPAGLDRIDAEPLTEADIALILRSAVSGAPLGHDDRTSDLRLSIAGA
QEKTALLRQQGLWFRPRGSTPTTHILKLPLGLVGAMQADMHESVENEWLCAQLAAAYGLAVARCEIAHFEDQKALVIERF
DRRFTDAGAIVRLPQEDMCQALGISPLRKYQADGGPGITAIIKNVLNSSQREQDVLDFYKAQIFFWMLAATDGHAKNFSI
ALLAGGRYHATPLYDILSAHPIIGTRRAQLAPQRAKLAMGVKGASGLHYRLAEIRRRHWYTHAHEIGLDAASVDGIMREL
IDATEPAIEHIAARLPRHFPARVAESIFAGLRSQRDKLLQQDSEVV

Download         Length: 1341 bp

>T75991 NZ_CP021108:6007501-6008841 [Bordetella genomosp. 8]
ATGGCGCGGAAGCCACTTCAGCTGAACATCTGGATGAACGGTTCGGCAGTCGGCGCGTGGCGCAACGAACCGGGCGGCTC
TTCGCTGACGTACAGCGAGGCCTGGATCAACGATCCGGGCGGCCGCCCGCTCTCCCTGTCGCTGCCCTTCCGCCTGGGCA
ACACGCCCTACAAGGGCGCGATCGTTGATGACTTCTTCGATAACCTGCTGCCGGACAGCGACGTCATCCGGCGCCGGCTG
GCGCAGCACCACCGCGCCGACAGCGCCGCTCCCTTCGACCTGTTGGCGGTGCTGGGCCGCGACTGCGTCGGCGCCATCCA
ATTGCTGCCACCGCATGAAGTCCCGGCCGGCCTGGACCGCATCGATGCCGAACCACTGACCGAAGCCGATATCGCGCTGA
TCCTGAGATCGGCCGTCAGCGGCGCGCCGCTGGGTCACGACGACCGTACCAGCGACCTGCGGCTCTCGATCGCCGGCGCA
CAGGAGAAAACCGCCCTGCTGCGCCAGCAGGGCCTATGGTTCCGTCCGCGCGGCAGCACACCGACCACGCATATCCTGAA
ACTGCCCCTGGGCCTGGTGGGCGCCATGCAGGCCGACATGCACGAATCCGTCGAGAACGAATGGCTATGCGCGCAGCTGG
CCGCCGCGTACGGCCTGGCAGTCGCCCGTTGCGAAATCGCGCACTTCGAAGACCAGAAAGCGCTGGTCATCGAGCGTTTC
GACCGCCGCTTCACGGATGCGGGTGCCATCGTCCGTCTGCCACAGGAAGACATGTGCCAGGCGCTGGGCATATCGCCGCT
GCGCAAATACCAGGCGGACGGCGGACCAGGGATCACCGCCATCATCAAGAACGTACTGAACTCGTCGCAGCGCGAACAGG
ACGTCCTCGACTTCTACAAGGCACAGATCTTTTTCTGGATGCTGGCCGCCACCGATGGCCATGCCAAGAATTTCAGCATT
GCCCTGCTGGCCGGCGGCAGATACCACGCGACGCCGCTGTACGACATCCTTTCGGCGCACCCCATCATCGGCACCAGGCG
CGCGCAGCTCGCGCCGCAGCGCGCCAAACTGGCGATGGGCGTGAAAGGGGCCAGCGGATTGCATTACCGCCTCGCCGAGA
TCCGCCGCCGGCACTGGTACACGCACGCGCACGAAATCGGGCTGGATGCCGCGTCGGTGGACGGCATCATGCGGGAACTC
ATCGATGCGACCGAGCCCGCCATCGAGCACATCGCCGCAAGACTGCCACGGCATTTTCCCGCGCGTGTCGCGGAATCGAT
CTTCGCCGGGTTGCGCTCGCAGCGCGATAAGCTCTTGCAGCAGGACAGCGAGGTGGTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.97 Da        Isoelectric Point: 11.1414

>AT75991 WP_086067457.1 NZ_CP021108:6007248-6007499 [Bordetella genomosp. 8]
MDFPVRTLQQLRPVLQGFRKAKGLTQAQLAARLGISQQSYAKLEAAPAKASVERLFTVLQMLRVEVHLRPMDQQDANASR
LEW

Download         Length: 252 bp

>AT75991 NZ_CP021108:6007248-6007499 [Bordetella genomosp. 8]
ATGGACTTCCCCGTCCGCACCCTGCAGCAACTACGGCCCGTGCTGCAAGGCTTCCGCAAGGCCAAGGGCCTGACCCAGGC
ACAACTCGCGGCACGGCTGGGCATCAGCCAGCAAAGCTACGCCAAACTGGAGGCCGCGCCCGCCAAGGCCAGCGTCGAAC
GCCTGTTCACCGTCCTGCAAATGCTGCGCGTGGAAGTCCACCTGCGCCCCATGGACCAGCAGGACGCCAACGCGTCCAGG
TTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References