Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1438540..1439063 Replicon chromosome
Accession NZ_CP021067
Organism Burkholderia cenocepacia strain PC184 Mulks

Toxin (Protein)


Gene name relE Uniprot ID A0A7G6V603
Locus tag B9Z07_RS06575 Protein ID WP_006480834.1
Coordinates 1438797..1439063 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1K8I6
Locus tag B9Z07_RS06570 Protein ID WP_011547275.1
Coordinates 1438540..1438800 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9Z07_RS06540 1433910..1435118 - 1209 WP_006480841.1 acetate/propionate family kinase -
B9Z07_RS06545 1435129..1436100 - 972 WP_006480840.1 phosphate acetyltransferase -
B9Z07_RS06550 1436248..1437123 + 876 WP_034175399.1 ATP synthase F1 subunit gamma -
B9Z07_RS06555 1437134..1437592 + 459 WP_023476056.1 ATP synthase F1 subunit epsilon -
B9Z07_RS06560 1437615..1437833 - 219 WP_006480837.1 DUF1653 domain-containing protein -
B9Z07_RS06565 1437891..1438334 - 444 WP_023476055.1 GNAT family N-acetyltransferase -
B9Z07_RS06570 1438540..1438800 + 261 WP_011547275.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B9Z07_RS06575 1438797..1439063 + 267 WP_006480834.1 Txe/YoeB family addiction module toxin Toxin
B9Z07_RS06580 1439113..1439736 + 624 WP_006480833.1 HAD hydrolase-like protein -
B9Z07_RS06585 1440143..1440721 + 579 WP_006480832.1 DUF4142 domain-containing protein -
B9Z07_RS06590 1440838..1441437 - 600 WP_034175218.1 GNAT family N-acetyltransferase -
B9Z07_RS06595 1441497..1442411 - 915 WP_011547270.1 LysR family transcriptional regulator -
B9Z07_RS06600 1442520..1443758 + 1239 WP_006480829.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10556.88 Da        Isoelectric Point: 7.9861

>T75942 WP_006480834.1 NZ_CP021067:1438797-1439063 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQLSI
VSCRYHYE

Download         Length: 267 bp

>T75942 NZ_CP021067:1438797-1439063 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAACTCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9745.00 Da        Isoelectric Point: 6.0717

>AT75942 WP_011547275.1 NZ_CP021067:1438540-1438800 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT75942 NZ_CP021067:1438540-1438800 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G6V603

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9NJ62

References