Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 60568..61235 Replicon plasmid pA
Accession NZ_CP020980
Organism Xanthomonas citri pv. phaseoli var. fuscans strain CFBP6988R

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag XcfCFBP6988P_RS23410 Protein ID WP_022557732.1
Coordinates 60819..61235 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag XcfCFBP6988P_RS23405 Protein ID WP_022557731.1
Coordinates 60568..60822 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcfCFBP6988P_RS23390 55746..56704 - 959 Protein_59 IS3-like element ISXcd1 family transposase -
XcfCFBP6988P_RS23395 56737..59766 - 3030 WP_022560486.1 Tn3 family transposase -
XcfCFBP6988P_RS23400 59763..60356 - 594 WP_022560487.1 recombinase family protein -
XcfCFBP6988P_RS23405 60568..60822 + 255 WP_022557731.1 plasmid stability protein Antitoxin
XcfCFBP6988P_RS23410 60819..61235 + 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
XcfCFBP6988P_RS23415 61249..61803 + 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
XcfCFBP6988P_RS23420 61878..62015 - 138 Protein_65 transposase -
XcfCFBP6988P_RS23425 62085..62615 - 531 Protein_66 DNA topoisomerase III -
XcfCFBP6988P_RS23430 62767..64059 - 1293 WP_033481893.1 hypothetical protein -
XcfCFBP6988P_RS23435 64186..65505 - 1320 WP_022557736.1 DUF4990 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..77006 77006
- inside IScluster/Tn - - 55746..62015 6269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T75854 WP_022557732.1 NZ_CP020980:60819-61235 [Xanthomonas citri pv. phaseoli var. fuscans]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T75854 NZ_CP020980:60819-61235 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGATCGTTCTCGATACCAACGTCGTTTCCGAGGCGATGAAGCCCGAGCCGCACCCATCCGTGCGGACCTGGTTGAACGA
TCAAGCCGCTGAAACACTGTACCTGTCCAGCGTGACGCTGGCCGAACTGCTATTTGGCATCGCTGCGCTTCCTGCCGGTA
AGCGCAAGGACATGCTGGAACAGGCCCTTGATGGCCTCATGGGCCTGTTTAGGGATCGGGTGTTGCCATTCGACATCGAT
GCAGCGCGGCGTTATGCCGAATTGGCCGTGACGGCAAAGATCGGAGGGCGAGGATTTCCGACACCCGACGGCTACATCGC
AGCGATTGCTGCCTCGCGGGGTTTCATTGTGGCGTCACGCGACACGGCCCCTTACGAAGCGGCCGGCGTAACCGTCATCA
ATCCGTGGGAAGGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT75854 WP_022557731.1 NZ_CP020980:60568-60822 [Xanthomonas citri pv. phaseoli var. fuscans]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT75854 NZ_CP020980:60568-60822 [Xanthomonas citri pv. phaseoli var. fuscans]
ATGGCAATGCTGACAGTACGTAATCTGCCGGATGATGTGCACCGCGCATTGCGCATGCGGGCCGCTCAAAATGGGCACAG
CACCGAGGCCGAGGTCCGCGAGATTCTGGCGACCGCAGTCAAGCCAGAGACGCGCGTTCGCCTAGGCGAAGCCTTGGCGG
CTTTGGGTCGCAAGATTGGCCTGACGAATGAGGACTTCGAGGTCTTCGATCGGGTAAGAGACAAGACGCCGGCCGTCCCG
CCGAGGCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References