Detailed information of TA system TA075704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 4157444..4157979
• Replicon: chromosome
• Accession: NZ_CP020931
• Organism: Marinobacter salarius strain SMR5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MARSALSMR5_RS19070
• Protein ID: WP_085681812.1
• Coordinates: 4157444..4157740 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: W5YS42
• Locus tag: MARSALSMR5_RS19075
• Protein ID: WP_041334363.1
• Coordinates: 4157740..4157979 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MARSALSMR5_RS19045	4153247..4154332	+	1086	WP_085681807.1	aldo/keto reductase	-
MARSALSMR5_RS19050	4154400..4154834	-	435	WP_085681808.1	GFA family protein	-
MARSALSMR5_RS19055	4154871..4155809	-	939	WP_085681809.1	carbon-nitrogen hydrolase family protein	-
MARSALSMR5_RS19060	4155954..4156637	+	684	WP_085681810.1	helix-turn-helix transcriptional regulator	-
MARSALSMR5_RS19065	4156845..4157426	+	582	WP_169052519.1	DUF2959 domain-containing protein	-
MARSALSMR5_RS19070	4157444..4157740	-	297	WP_085681812.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MARSALSMR5_RS19075	4157740..4157979	-	240	WP_041334363.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MARSALSMR5_RS19080	4158423..4159055	+	633	WP_085681813.1	glutathione S-transferase family protein	-
MARSALSMR5_RS19085	4159282..4159896	+	615	WP_085681814.1	class I SAM-dependent methyltransferase	-
MARSALSMR5_RS19090	4159939..4160151	+	213	WP_036202542.1	hypothetical protein	-
MARSALSMR5_RS19095	4160248..4161069	+	822	WP_085681815.1	VOC family protein	-
MARSALSMR5_RS19100	4161094..4161579	+	486	WP_085681816.1	VOC family protein	-
MARSALSMR5_RS19105	4161594..4162484	-	891	WP_085681817.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11534.23 Da
• Isoelectric Point: 9.0422

>T75704 WP_085681812.1 NZ_CP020931:c4157740-4157444 [Marinobacter salarius]
MPNFKLSRKTKADLRSIALYTERKWGRDQRNHYLLQFDQCFHLLDENPNLGQACHEISPGYQQYPQGSHIIFYRLAADGA
TEIIRILHKRMLPEGHLL

Nucleotide

• Length: 297 bp

>T75704 NZ_CP020931:c4157740-4157444 [Marinobacter salarius]
ATGCCAAACTTCAAGCTTTCCAGGAAGACCAAAGCTGATCTTAGATCGATTGCACTTTACACGGAACGTAAATGGGGTCG
AGATCAACGAAATCATTACCTCCTTCAGTTCGACCAGTGTTTCCACCTCCTGGACGAAAACCCGAACCTGGGGCAGGCCT
GCCACGAAATCAGCCCTGGCTATCAGCAATACCCTCAGGGCAGCCATATCATTTTTTATCGGTTAGCTGCAGACGGTGCA
ACTGAAATTATCCGGATCCTTCATAAGCGCATGTTGCCCGAGGGACATTTGCTATAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9138.10 Da
• Isoelectric Point: 4.6536

>AT75704 WP_041334363.1 NZ_CP020931:c4157979-4157740 [Marinobacter salarius]
MQKNTSITLGQHFDAFITEQLKNGRYSSTSEVVRAGLRLLEESETRLTTLRKLLKEGEDSGFEDYSYDSFIQELDSEKR

Nucleotide

• Length: 240 bp

>AT75704 NZ_CP020931:c4157979-4157740 [Marinobacter salarius]
ATGCAAAAGAATACCAGCATCACTTTAGGCCAACACTTTGATGCGTTCATTACAGAACAGCTCAAAAATGGCCGATACAG
CTCGACCAGCGAAGTTGTACGTGCAGGGTTGCGCTTGCTTGAAGAGTCTGAAACCCGTCTGACAACACTCCGAAAACTAC
TTAAGGAAGGAGAGGACAGTGGTTTTGAAGACTACTCCTACGATTCATTCATTCAGGAGCTGGATAGCGAAAAACGGTAA

Structures

Antitoxin

• AlphaFold DB: W5YS42