Detailed information of TA system TA075703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4147761..4148308
• Replicon: chromosome
• Accession: NZ_CP020931
• Organism: Marinobacter salarius strain SMR5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MARSALSMR5_RS19000
• Protein ID: WP_085681804.1
• Coordinates: 4148006..4148308 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5YSC8
• Locus tag: MARSALSMR5_RS18995
• Protein ID: WP_041334385.1
• Coordinates: 4147761..4148018 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MARSALSMR5_RS18980	4144319..4145224	+	906	WP_085681801.1	hydroxymethylglutaryl-CoA lyase	-
MARSALSMR5_RS18985	4145224..4145802	+	579	WP_085681802.1	peroxidase-related enzyme	-
MARSALSMR5_RS18990	4145854..4147542	+	1689	WP_085681803.1	AMP-binding protein	-
MARSALSMR5_RS18995	4147761..4148018	+	258	WP_041334385.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MARSALSMR5_RS19000	4148006..4148308	+	303	WP_085681804.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MARSALSMR5_RS19005	4148402..4148896	+	495	WP_041334381.1	ATP-binding protein	-
MARSALSMR5_RS19010	4149018..4149302	+	285	WP_036206823.1	IS3 family transposase	-
MARSALSMR5_RS19015	4149299..4150153	+	855	WP_081899272.1	IS3 family transposase	-
MARSALSMR5_RS19020	4150286..4150609	+	324	WP_085681805.1	hypothetical protein	-
MARSALSMR5_RS19025	4150774..4151172	+	399	WP_157665626.1	hypothetical protein	-
MARSALSMR5_RS19030	4151186..4151752	+	567	WP_075195382.1	GNAT family N-acetyltransferase	-
MARSALSMR5_RS19035	4151788..4152105	+	318	WP_041334370.1	antibiotic biosynthesis monooxygenase	-
MARSALSMR5_RS19040	4152118..4153050	-	933	WP_087149031.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4138054..4152105	14051

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11504.26 Da
• Isoelectric Point: 4.5463

>T75703 WP_085681804.1 NZ_CP020931:4148006-4148308 [Marinobacter salarius]
MAEVIWTEPALQELSAIAEYIALDNPAAASRLVEEVFDKTDRLEGFPQSGRIPPELPNSVYREVVVPPCRIFYREDKTRV
FVLFVMREERLLRAYMLGSS

Nucleotide

• Length: 303 bp

>T75703 NZ_CP020931:4148006-4148308 [Marinobacter salarius]
ATGGCTGAAGTAATCTGGACTGAGCCGGCCCTTCAAGAGTTAAGCGCAATCGCAGAGTACATTGCTCTGGATAATCCCGC
CGCTGCAAGCCGCCTGGTAGAAGAGGTTTTCGATAAAACCGACCGTTTGGAAGGTTTTCCGCAGTCCGGGCGGATTCCTC
CAGAGCTTCCTAATTCGGTATACAGGGAAGTAGTTGTTCCACCGTGTCGCATTTTTTATCGTGAGGATAAGACGCGGGTT
TTTGTCCTCTTTGTCATGCGAGAGGAGAGGCTGCTTCGTGCATACATGCTTGGGAGCAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9928.47 Da
• Isoelectric Point: 8.5042

>AT75703 WP_041334385.1 NZ_CP020931:4147761-4148018 [Marinobacter salarius]
MKIELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQNEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT75703 NZ_CP020931:4147761-4148018 [Marinobacter salarius]
ATGAAAATTGAGCTTGTTACAAACCTTAAGCGCCAAGCTACAAAAATCTTGGCAGACCTGCATCTGTCTAAAGAGCCGGT
ATTGATCACCGAGCATGGCCAGCCATCGGCTTATCTTGTTGATGTGCAGGATTACGAATTCATGCAGCGTCGGCTTGAGC
TACTTGAAGGGCTCTCACGAGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGTCAAAATGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: W5YSC8