Detailed information of TA system TA075697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3575170..3575828
• Replicon: chromosome
• Accession: NZ_CP020925
• Organism: Sphingobium yanoikuyae strain SHJ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A084EIW7
• Locus tag: BV87_RS16940
• Protein ID: WP_037520637.1
• Coordinates: 3575391..3575828 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BV87_RS16935
• Protein ID: WP_196221871.1
• Coordinates: 3575170..3575394 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV87_RS16905	3571036..3571302	+	267	WP_037520626.1	hypothetical protein	-
BV87_RS16910	3571379..3571654	+	276	WP_037520628.1	HU family DNA-binding protein	-
BV87_RS16915	3572251..3573009	+	759	WP_037520629.1	LuxR family transcriptional regulator	-
BV87_RS16920	3573148..3573762	+	615	WP_048937925.1	autoinducer synthase	-
BV87_RS16925	3573774..3574673	+	900	WP_037520632.1	phytanoyl-CoA dioxygenase family protein	-
BV87_RS16930	3574716..3575138	+	423	WP_048937926.1	MarR family winged helix-turn-helix transcriptional regulator	-
BV87_RS16935	3575170..3575394	+	225	WP_196221871.1	CopG family transcriptional regulator	Antitoxin
BV87_RS16940	3575391..3575828	+	438	WP_037520637.1	PIN domain-containing protein	Toxin
BV87_RS16945	3575828..3576748	+	921	WP_037520638.1	HEPN domain-containing protein	-
BV87_RS16950	3577252..3577800	-	549	WP_017500760.1	hypothetical protein	-
BV87_RS16955	3578107..3578697	+	591	WP_048937927.1	TerD family protein	-
BV87_RS16960	3578749..3579972	+	1224	WP_048937928.1	TerD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3553513..3705923	152410

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15628.87 Da
• Isoelectric Point: 6.7650

>T75697 WP_037520637.1 NZ_CP020925:3575391-3575828 [Sphingobium yanoikuyae]
MTYLLDVNVLVALIDPNHVGHEAAHHWFETEGGKAWATCPITENGVIRIVGNVRYPSTPGSPAEVASIMAQMCKLPGHRF
WAEDISLLSAEHVDASHILTSAQVTDTYLLALAVANKGKLATFDRRLTPKGVTGGKDAIHLIGNH

Nucleotide

• Length: 438 bp

>T75697 NZ_CP020925:3575391-3575828 [Sphingobium yanoikuyae]
ATGACCTATCTTCTTGACGTCAATGTCCTGGTCGCGCTGATCGACCCCAATCATGTCGGGCATGAGGCGGCGCATCACTG
GTTCGAGACCGAAGGCGGCAAGGCCTGGGCGACCTGCCCCATCACCGAGAATGGCGTGATCCGGATCGTCGGCAATGTCC
GCTACCCTTCGACACCCGGCTCGCCGGCTGAGGTCGCGTCGATCATGGCGCAAATGTGCAAGCTTCCGGGTCACCGCTTC
TGGGCCGAGGATATCAGCCTGCTGTCTGCCGAGCATGTCGACGCCAGCCATATCCTCACTTCCGCGCAGGTGACCGACAC
CTATCTCCTCGCCCTGGCCGTCGCTAATAAGGGCAAGCTTGCGACTTTCGACCGGCGGCTCACCCCAAAGGGGGTGACCG
GCGGCAAGGACGCGATCCACCTCATCGGAAATCATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7908.05 Da
• Isoelectric Point: 7.3199

>AT75697 WP_196221871.1 NZ_CP020925:3575170-3575394 [Sphingobium yanoikuyae]
MRTTLVIDDDVMAAARAIADHQHSSIGRVLSDLARKALHAPEAARTRNGISLLPTKPGVVVTQDIVNALRDEAP

Nucleotide

• Length: 225 bp

>AT75697 NZ_CP020925:3575170-3575394 [Sphingobium yanoikuyae]
ATGCGGACGACCCTGGTGATCGATGATGATGTGATGGCGGCGGCGCGCGCGATCGCCGATCATCAGCACAGCTCGATTGG
CCGTGTCCTCTCGGATCTGGCCCGCAAGGCGCTGCATGCGCCGGAAGCGGCTCGCACGCGCAACGGCATCAGCTTACTTC
CGACCAAGCCGGGTGTGGTAGTGACGCAGGACATCGTCAATGCCCTTCGCGATGAGGCGCCATGA

Structures

Toxin

• AlphaFold DB: A0A084EIW7