Detailed information of TA system TA075696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 2708350..2708988
• Replicon: chromosome
• Accession: NZ_CP020925
• Organism: Sphingobium yanoikuyae strain SHJ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BV87_RS12890
• Protein ID: WP_048938827.1
• Coordinates: 2708587..2708988 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0J9FLQ9
• Locus tag: BV87_RS12885
• Protein ID: WP_010338822.1
• Coordinates: 2708350..2708583 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV87_RS12855	2703971..2704105	+	135	WP_107917581.1	benenodin family lasso peptide	-
BV87_RS12870	2706029..2706859	+	831	WP_048938830.1	PRTRC system protein B	-
BV87_RS12875	2706856..2707515	+	660	WP_048938829.1	PRTRC system protein A	-
BV87_RS12880	2707505..2708314	+	810	WP_048938828.1	PRTRC system ThiF family protein	-
BV87_RS12885	2708350..2708583	+	234	WP_010338822.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BV87_RS12890	2708587..2708988	+	402	WP_048938827.1	type II toxin-antitoxin system VapC family toxin	Toxin
BV87_RS12895	2709180..2710442	+	1263	WP_048938826.1	hypothetical protein	-
BV87_RS12900	2710669..2711118	+	450	WP_107917681.1	hypothetical protein	-
BV87_RS12905	2711253..2711714	+	462	WP_048938825.1	hypothetical protein	-
BV87_RS12910	2711731..2712813	+	1083	WP_048938824.1	hypothetical protein	-
BV87_RS27695	2712906..2713070	-	165	WP_199909654.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2653458..2882789	229331

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (10-55)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14437.62 Da
• Isoelectric Point: 4.7363

>T75696 WP_048938827.1 NZ_CP020925:2708587-2708988 [Sphingobium yanoikuyae]
MFLLDTNILSDLIRQPDGMVAHAIADVGEDAVATSIIVAGELRYGAEKRGSPRLKSKIEDLLSLIAVLPLKDDADACYGR
LRADLERRGTPIGANDMLIAAHALAIGATLVTDNIREFERVDGLQLVNWLRTT

Nucleotide

• Length: 402 bp

>T75696 NZ_CP020925:2708587-2708988 [Sphingobium yanoikuyae]
ATGTTCCTGCTCGATACGAATATCCTGTCGGACCTGATCCGACAGCCCGATGGCATGGTCGCCCACGCTATCGCCGACGT
CGGCGAGGATGCGGTTGCGACCAGCATCATCGTTGCCGGCGAACTGCGCTATGGCGCAGAAAAGCGCGGATCGCCGCGCC
TGAAAAGCAAGATCGAGGATTTGCTGTCTCTCATTGCGGTGCTGCCGCTCAAGGACGATGCCGACGCCTGCTATGGGCGT
CTGCGTGCCGACCTCGAGCGCCGTGGCACGCCGATCGGCGCTAACGATATGCTGATCGCCGCCCACGCGCTCGCAATCGG
CGCGACCCTCGTTACCGACAACATCCGCGAATTCGAGCGGGTCGATGGCTTGCAACTGGTGAACTGGCTCCGAACCACCT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8809.19 Da
• Isoelectric Point: 4.8723

>AT75696 WP_010338822.1 NZ_CP020925:2708350-2708583 [Sphingobium yanoikuyae]
MNLERHVKLFKNGRSQAVRIPREFELPGEDAIIRKEGSRLIIEPARPRSLLAVLKTWEPLDEEIGPIEDLPAEPVDI

Nucleotide

• Length: 234 bp

>AT75696 NZ_CP020925:2708350-2708583 [Sphingobium yanoikuyae]
ATGAACCTCGAGCGTCACGTCAAACTGTTCAAGAACGGCCGCAGCCAGGCGGTCCGCATTCCCCGTGAGTTCGAGCTTCC
GGGCGAGGACGCCATTATCCGCAAGGAAGGCTCGCGCCTGATCATCGAACCCGCCCGGCCGCGCTCCCTGCTTGCCGTTC
TCAAGACATGGGAACCGCTCGATGAAGAGATCGGCCCGATCGAGGACCTGCCGGCAGAACCGGTCGACATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0J9FLQ9