Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2123549..2125175 Replicon chromosome
Accession NZ_CP020820
Organism Pantoea vagans strain FBS135

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B9D02_RS10090 Protein ID WP_110411405.1
Coordinates 2123850..2125175 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B9D02_RS10085 Protein ID WP_003853607.1
Coordinates 2123549..2123845 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9D02_RS10070 2119024..2120406 + 1383 WP_110411401.1 M24 family metallopeptidase -
B9D02_RS10075 2120521..2122566 + 2046 WP_110411403.1 FUSC family protein -
B9D02_RS10080 2122906..2123241 - 336 WP_008925196.1 gamma-glutamylcyclotransferase -
B9D02_RS10085 2123549..2123845 + 297 WP_003853607.1 helix-turn-helix domain-containing protein Antitoxin
B9D02_RS10090 2123850..2125175 + 1326 WP_110411405.1 type II toxin-antitoxin system HipA family toxin Toxin
B9D02_RS10095 2125565..2126584 - 1020 WP_078804402.1 alpha/beta hydrolase -
B9D02_RS10100 2127075..2127497 + 423 WP_003853600.1 hydroxyisourate hydrolase -
B9D02_RS10105 2127514..2128431 - 918 WP_110411408.1 LysR family transcriptional regulator -
B9D02_RS10110 2128579..2129328 + 750 WP_039660238.1 glucose 1-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50173.13 Da        Isoelectric Point: 6.0674

>T75451 WP_110411405.1 NZ_CP020820:2123850-2125175 [Pantoea vagans]
MSRRQQRLVIWMNGIQVGFWNKSKGEDTLQYLPEWSADAQGRPLSLSLPFTPGDQIWRGNVVRDYFDNLLPDSEGIRRRL
AMRYQAESLDPFDLLTELGKDCVGAIQLLKEGDEPTDLYCVKYRPLSESEIAMTLRNTTAASLPGRQSDTGDLRLSIAGA
QEKTALLWHDDRWCKPEGNTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLLLEQFGIPVARTEIAQFEDQKVLVVERF
DRKWSGDQRWIIRLPQEDMCQAAGMSPLRKYQADGGPGISEIMEILSHSDHAEQDRLHFFKAQIIFWVLAATDGHAKNFS
IAIGPQGHYCLTPLYDVLSAWPVIGNGNNQIAWQKCKLAMAARGSSNYYKLYRIQRRHWINHGEQTGLSKKQVEMMMDEI
ISDAPDVIERVRAQLPDQFPSELAERMFDGITQQCRRLAGN

Download         Length: 1326 bp

>T75451 NZ_CP020820:2123850-2125175 [Pantoea vagans]
ATGAGCCGGAGACAGCAGCGTTTAGTGATATGGATGAACGGTATTCAGGTTGGATTCTGGAACAAAAGCAAAGGAGAAGA
CACGCTGCAATATCTTCCTGAATGGAGTGCCGACGCGCAAGGAAGACCGTTATCGCTCTCTTTGCCTTTTACCCCCGGCG
ATCAAATCTGGCGCGGAAATGTGGTACGTGACTATTTTGATAATTTATTACCAGACAGTGAAGGGATTCGCAGGCGTCTG
GCTATGCGGTATCAGGCAGAAAGTCTCGACCCTTTTGACCTGTTGACCGAGCTGGGAAAAGATTGCGTAGGCGCGATACA
GTTACTGAAAGAGGGCGATGAACCCACGGATTTATATTGCGTAAAATATCGGCCGCTCTCTGAATCAGAGATCGCAATGA
CATTGCGAAATACCACGGCGGCATCATTACCCGGCAGACAGAGTGATACAGGCGACTTACGGCTATCCATTGCCGGTGCG
CAGGAAAAAACAGCGTTATTATGGCATGACGATCGGTGGTGCAAGCCTGAAGGGAATACGCCAACGACGCATATTTTCAA
GTTGCCGCTTGGCCTGGTCGGCAATATGAAAGCTGATATGAGTACATCCGTGGAAAACGAATGGCTCTGTTCGCTGCTAC
TTGAACAATTCGGCATCCCGGTCGCAAGAACAGAAATCGCTCAATTCGAAGATCAGAAAGTCCTGGTGGTTGAACGTTTT
GACCGCAAATGGTCAGGTGATCAGCGGTGGATCATTCGTTTACCTCAGGAAGATATGTGTCAGGCTGCGGGGATGTCACC
ATTACGCAAATATCAGGCCGACGGCGGGCCAGGTATCTCTGAAATTATGGAGATTCTGAGTCATTCAGATCACGCAGAAC
AGGACAGATTGCATTTCTTTAAAGCACAGATAATTTTCTGGGTACTGGCGGCCACAGATGGCCATGCTAAAAATTTCAGT
ATTGCGATAGGGCCTCAGGGGCATTATTGCCTTACGCCACTTTATGATGTTTTATCGGCATGGCCGGTCATCGGAAATGG
CAATAATCAGATAGCCTGGCAAAAATGCAAACTGGCGATGGCCGCTCGCGGCAGCAGCAACTATTACAAACTCTACAGAA
TACAAAGACGGCACTGGATTAACCACGGTGAGCAGACCGGCCTGAGTAAAAAGCAGGTTGAGATGATGATGGATGAAATA
ATTTCTGACGCACCGGACGTCATCGAGCGTGTTCGCGCGCAACTGCCAGATCAGTTCCCGTCAGAACTGGCAGAACGCAT
GTTTGATGGCATAACGCAGCAATGCAGGCGTCTGGCCGGAAATTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10935.65 Da        Isoelectric Point: 10.8315

>AT75451 WP_003853607.1 NZ_CP020820:2123549-2123845 [Pantoea vagans]
MKNVYPIKTLSQLRPLLIGFRKANGLTQKDLSERLGVTQQTYARLEANPARASIERLFKIFTLLGVEMTLSSGISSSAGK
PTEEKGTLENSPARREKW

Download         Length: 297 bp

>AT75451 NZ_CP020820:2123549-2123845 [Pantoea vagans]
ATGAAAAATGTCTATCCGATAAAAACACTCAGCCAGTTGCGTCCTTTGCTTATTGGTTTTCGCAAAGCAAATGGACTGAC
GCAAAAAGATCTGTCTGAACGATTAGGCGTCACTCAGCAGACTTATGCGCGTCTGGAAGCCAACCCGGCCAGAGCCAGCA
TTGAACGCCTCTTCAAAATCTTCACACTGCTGGGCGTGGAGATGACTCTCTCTTCGGGAATAAGCTCATCCGCAGGAAAG
CCGACAGAAGAAAAGGGGACGTTAGAAAATTCACCTGCGAGACGGGAGAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References