Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2116856..2118414 Replicon chromosome
Accession NZ_CP020820
Organism Pantoea vagans strain FBS135

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B9D02_RS10060 Protein ID WP_110411399.1
Coordinates 2117104..2118414 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B9D02_RS10055 Protein ID WP_003853619.1
Coordinates 2116856..2117104 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B9D02_RS10035 2112111..2114336 + 2226 WP_008925203.1 iron ABC transporter permease -
B9D02_RS10040 2114333..2115394 + 1062 WP_003853623.1 ABC transporter ATP-binding protein -
B9D02_RS10045 2115418..2116212 + 795 WP_039660226.1 inositol monophosphatase -
B9D02_RS10050 2116242..2116679 - 438 WP_110411398.1 GNAT family N-acetyltransferase -
B9D02_RS10055 2116856..2117104 + 249 WP_003853619.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
B9D02_RS10060 2117104..2118414 + 1311 WP_110411399.1 type II toxin-antitoxin system HipA family toxin Toxin
B9D02_RS10065 2118516..2118722 + 207 WP_003853616.1 type II toxin-antitoxin system MqsA family antitoxin -
B9D02_RS10070 2119024..2120406 + 1383 WP_110411401.1 M24 family metallopeptidase -
B9D02_RS10075 2120521..2122566 + 2046 WP_110411403.1 FUSC family protein -
B9D02_RS10080 2122906..2123241 - 336 WP_008925196.1 gamma-glutamylcyclotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49024.34 Da        Isoelectric Point: 6.8328

>T75450 WP_110411399.1 NZ_CP020820:2117104-2118414 [Pantoea vagans]
MQRLIAWMNGERVGVLTRQRNGTHAFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRERIAARYQ
TQSCEPFDLLQEVGRDTVGAIMLLPPDRPLPAVQARYEVLDEARLESVLSARYDIPLGMLHEEPDFRLSVAGAQEKTALL
LSQEGWSIPAGGTSASHIIKLPVGEIKQPTATLDMRESVENEYLCLTLARALGINVPQATIIRAGKMRALAVERFDRRWS
RDKTRLIRLPQEDFCQALGLTSSTQYESDGGPGIAEIMQILMGSRHAIEDRYRFMMFQVFQWLIGATDGHARNFSLFIER
GGSYRLTPFYDVISAYPVQSGSGMNTQALTLAMGLGATQEKRTEIDKIYPRHFIATAKQVSFDRDSLQQIFDFFIKALPQ
AIVLVRDALPPDFPQHIADAIFSHALIMLERLRHGE

Download         Length: 1311 bp

>T75450 NZ_CP020820:2117104-2118414 [Pantoea vagans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAACGGGTGGGTGTACTGACACGGCAGCGAAACGGCACCCATGCGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCCGGCCGCTGTCACTCTCAATGCCATTGCAGGTTAAGGCGATCACAT
CACACGCTGTGATTAACTTCTTCGATAACCTGCTGCCGGACAGCCCACTGATTCGTGAGAGAATCGCAGCGCGTTACCAG
ACTCAATCCTGTGAGCCCTTTGATTTACTGCAGGAGGTGGGACGTGACACCGTCGGAGCAATCATGCTGTTGCCGCCCGA
CAGGCCATTGCCTGCCGTGCAGGCTCGTTATGAGGTGCTGGATGAAGCCCGGCTCGAAAGCGTACTGTCGGCCAGGTACG
ATATTCCGCTGGGAATGTTGCATGAGGAGCCCGATTTCCGCCTCTCAGTTGCGGGTGCACAGGAGAAAACCGCGCTGCTG
CTGTCGCAGGAAGGCTGGAGCATTCCTGCCGGTGGCACGTCTGCCTCACACATCATTAAGCTGCCAGTCGGTGAGATTAA
ACAGCCGACCGCTACGCTGGATATGCGTGAAAGCGTAGAGAATGAGTATCTTTGTCTGACGCTGGCCCGCGCACTCGGTA
TCAATGTGCCGCAGGCGACCATTATCCGGGCCGGAAAGATGCGCGCCCTCGCCGTTGAACGCTTTGATCGCCGCTGGTCA
CGTGACAAAACCCGGCTGATTCGCCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGACTGACCTCGTCAACCCAATATGA
ATCGGATGGCGGGCCGGGCATCGCAGAGATCATGCAGATACTGATGGGATCACGTCACGCCATTGAAGATCGCTATCGCT
TTATGATGTTCCAGGTATTTCAGTGGCTGATTGGTGCCACCGACGGTCACGCCAGGAATTTCTCACTGTTTATTGAGCGC
GGCGGCAGTTACCGTCTGACCCCTTTTTATGATGTGATCTCCGCGTACCCGGTGCAGTCGGGTTCCGGCATGAACACGCA
AGCGCTGACACTGGCGATGGGGCTGGGCGCCACTCAGGAGAAGAGGACGGAGATCGACAAAATTTACCCGCGCCATTTTA
TCGCCACGGCGAAGCAGGTGAGTTTCGATCGTGACAGCCTGCAGCAGATCTTTGACTTCTTTATTAAAGCGCTTCCCCAG
GCAATCGTTTTGGTGCGTGATGCGTTGCCGCCCGACTTTCCTCAGCATATCGCCGACGCCATTTTCAGCCATGCATTGAT
TATGCTGGAGCGGTTACGGCATGGAGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9278.55 Da        Isoelectric Point: 6.2126

>AT75450 WP_003853619.1 NZ_CP020820:2116856-2117104 [Pantoea vagans]
MIYSPIQLANQLKFIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLAVQEKEAVTATHLHDED
EW

Download         Length: 249 bp

>AT75450 NZ_CP020820:2116856-2117104 [Pantoea vagans]
ATGATATACAGCCCGATACAGCTGGCAAACCAGCTCAAGTTTATCCGCCAGCGCAATGGCTGGACGCAGAGTGAGCTGGC
AAAAAAGGTCGGCCTGAAACAGGCTACCATTTCTCATTTTGAAAATGCGCCTGACAGCACCTCACTGGCCACGCTGTTTA
AGCTGTTACAGGCGCTGGAAGTGAGTCTGGCCGTTCAGGAAAAAGAGGCGGTCACGGCGACTCATTTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References