Detailed information of TA system TA075422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 136951..137495
• Replicon: plasmid unnamed2
• Accession: NZ_CP020811
• Organism: Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTO20_RS38015
• Protein ID: WP_087083676.1
• Coordinates: 136951..137229 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTO20_RS38020
• Protein ID: WP_087083678.1
• Coordinates: 137226..137495 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTO20_RS37985	132058..132402	-	345	WP_157680478.1	YbaB/EbfC family nucleoid-associated protein	-
BTO20_RS37990	132408..134018	-	1611	WP_087083666.1	PPE domain-containing protein	-
BTO20_RS37995	134037..134483	-	447	WP_198344628.1	hypothetical protein	-
BTO20_RS38000	134530..134856	-	327	WP_157680480.1	hypothetical protein	-
BTO20_RS38005	134960..135247	+	288	WP_087083672.1	hypothetical protein	-
BTO20_RS38010	135253..136470	-	1218	WP_087083674.1	C40 family peptidase	-
BTO20_RS38015	136951..137229	-	279	WP_087083676.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTO20_RS38020	137226..137495	-	270	WP_087083678.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BTO20_RS38025	137726..139129	+	1404	Protein_141	IS1380 family transposase	-
BTO20_RS39760	139386..139562	-	177	WP_157680481.1	hypothetical protein	-
BTO20_RS38035	139584..140666	-	1083	WP_087083682.1	hypothetical protein	-
BTO20_RS39765	140808..141269	-	462	WP_157680482.1	hypothetical protein	-
BTO20_RS38045	141343..141735	-	393	WP_157680483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..152685	152685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10541.15 Da
• Isoelectric Point: 10.5217

>T75422 WP_087083676.1 NZ_CP020811:c137229-136951 [Mycobacterium dioxanotrophicus]
VTDEHPWAVRLAPGAVRALDRLPHKVAAAIAEFITATLPTDPYRMSKPLRHELAGWRVARRGDYRVTFRILDDDHALLIG
RVEHRAHIYRPT

Nucleotide

• Length: 279 bp

>T75422 NZ_CP020811:c137229-136951 [Mycobacterium dioxanotrophicus]
GTGACCGACGAGCACCCATGGGCGGTCCGATTGGCTCCCGGCGCGGTTCGCGCACTCGATCGGCTTCCGCACAAAGTCGC
GGCCGCGATCGCCGAATTCATCACCGCGACACTGCCCACAGACCCGTACCGAATGTCGAAGCCGCTGCGGCACGAGCTCG
CCGGCTGGCGCGTCGCCCGGCGAGGCGACTATCGAGTCACCTTCCGCATCCTCGACGACGACCACGCCCTGCTGATCGGT
CGTGTTGAGCACCGGGCGCACATCTACCGCCCAACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9633.74 Da
• Isoelectric Point: 4.6267

>AT75422 WP_087083678.1 NZ_CP020811:c137495-137226 [Mycobacterium dioxanotrophicus]
MKTVPLSEAKDKLSALVDEADSTHEIIRITRHGRAAAVLMSADDLDSLNETLHALRTPGLVDELNQADADYAAGNTITGE
DLRKRYGLS

Nucleotide

• Length: 270 bp

>AT75422 NZ_CP020811:c137495-137226 [Mycobacterium dioxanotrophicus]
ATGAAGACGGTACCGCTCAGTGAAGCCAAGGACAAGCTTTCCGCCCTGGTCGACGAGGCCGACAGCACGCACGAAATCAT
CCGCATCACCCGACACGGCCGAGCCGCCGCGGTCTTGATGTCCGCCGACGACCTCGACTCGCTCAACGAAACCCTGCATG
CACTGCGTACCCCAGGGCTCGTCGACGAGCTCAACCAGGCCGACGCCGACTACGCCGCCGGCAACACCATCACCGGCGAA
GATCTTCGCAAACGCTACGGCCTCTCGTGA