Detailed information of TA system TA075351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1782011..1782711
• Replicon: chromosome
• Accession: NZ_CP020738
• Organism: Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: B7P44_RS25455
• Protein ID: WP_084908707.1
• Coordinates: 1782415..1782711 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: B7P44_RS25450
• Protein ID: WP_084908706.1
• Coordinates: 1782011..1782412 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P44_RS25430	1777688..1779037	-	1350	WP_084908702.1	LLM class flavin-dependent oxidoreductase	-
B7P44_RS25435	1779045..1780103	-	1059	WP_084908703.1	LLM class flavin-dependent oxidoreductase	-
B7P44_RS25440	1780152..1781093	-	942	WP_084908704.1	ABC transporter substrate-binding protein	-
B7P44_RS25445	1781142..1781696	-	555	WP_084908705.1	GNAT family N-acetyltransferase	-
B7P44_RS25450	1782011..1782412	-	402	WP_084908706.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B7P44_RS25455	1782415..1782711	-	297	WP_084908707.1	type II toxin-antitoxin system MqsR family toxin	Toxin
B7P44_RS25460	1782820..1783854	-	1035	WP_084910018.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
B7P44_RS25465	1784185..1784457	-	273	WP_084908708.1	hypothetical protein	-
B7P44_RS25470	1784669..1786216	-	1548	WP_084908709.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10995.73 Da
• Isoelectric Point: 8.9607

>T75351 WP_084908707.1 NZ_CP020738:c1782711-1782415 [Paraburkholderia acidophila]
MEKSTPHCKLSRVKALVETGKVRLTASAVIGARQLGFTEVEAIGVVMSLTAVDFHKSMTTYADHTIWQDVYQRDTSRGHV
YLKLTVIDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T75351 NZ_CP020738:c1782711-1782415 [Paraburkholderia acidophila]
ATGGAAAAGAGTACGCCTCACTGCAAGCTGTCCCGAGTCAAAGCGCTCGTCGAGACCGGCAAGGTGCGTCTGACCGCGAG
TGCGGTAATCGGCGCTCGGCAACTTGGCTTCACCGAAGTGGAAGCGATCGGCGTCGTGATGTCGCTGACAGCCGTCGATT
TCCACAAGAGCATGACGACCTATGCCGACCACACGATCTGGCAAGACGTGTATCAGCGCGACACGTCGCGTGGCCACGTG
TATCTGAAACTGACCGTGATCGACGACGTGCTGATCGTGTCTTTCAAGGAGCGTTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14329.78 Da
• Isoelectric Point: 9.5752

>AT75351 WP_084908706.1 NZ_CP020738:c1782412-1782011 [Paraburkholderia acidophila]
MKCPACGAAKLIRDTRDIPYTYKGRSTVVPGITGDFCPACGESVLAIAEATRLGEAVAAFNKQVNATIVDPKFIAKVRKK
LMLDQREAAELFGGGINAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Nucleotide

• Length: 402 bp

>AT75351 NZ_CP020738:c1782412-1782011 [Paraburkholderia acidophila]
ATGAAGTGCCCTGCGTGCGGTGCCGCAAAGCTGATCCGCGACACACGAGACATTCCCTATACCTACAAGGGTCGATCGAC
GGTCGTCCCCGGCATCACGGGCGATTTCTGTCCGGCCTGCGGAGAGTCGGTGCTGGCCATCGCCGAGGCGACCCGTCTCG
GCGAAGCGGTAGCGGCGTTCAACAAGCAGGTGAACGCGACCATCGTCGACCCGAAGTTCATTGCGAAGGTGCGCAAGAAG
CTGATGCTGGATCAGCGCGAGGCGGCCGAGCTCTTCGGCGGCGGGATCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
GAACCCGCCGCTCGCCCTGGTGAAGCTGTTGAAGATCCTGGACCGCCATCCGGATCTGCTTGCCGAAGTACGCGCGGCAT
AG