Detailed information of TA system TA075350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 939514..940155
• Replicon: chromosome
• Accession: NZ_CP020738
• Organism: Paraburkholderia acidophila strain ATCC 31433

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B7P44_RS21815
• Protein ID: WP_084908091.1
• Coordinates: 939817..940155 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2A4FM99
• Locus tag: B7P44_RS21810
• Protein ID: WP_059851409.1
• Coordinates: 939514..939813 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P44_RS21785	934764..936035	+	1272	WP_084908086.1	Rieske 2Fe-2S domain-containing protein	-
B7P44_RS21790	936050..936526	+	477	WP_084908087.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-
B7P44_RS21795	936546..936872	+	327	WP_084908088.1	non-heme iron oxygenase ferredoxin subunit	-
B7P44_RS21800	936862..938082	+	1221	WP_084908089.1	FAD-dependent oxidoreductase	-
B7P44_RS21805	938180..939466	+	1287	WP_084908090.1	DUF445 family protein	-
B7P44_RS21810	939514..939813	-	300	WP_059851409.1	putative addiction module antidote protein	Antitoxin
B7P44_RS21815	939817..940155	-	339	WP_084908091.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7P44_RS21820	940548..942188	+	1641	WP_084908092.1	acetolactate synthase large subunit	-
B7P44_RS21825	942211..943644	+	1434	WP_084908093.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (4-95)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12637.39 Da
• Isoelectric Point: 5.6062

>T75350 WP_084908091.1 NZ_CP020738:c940155-939817 [Paraburkholderia acidophila]
MVDTLLSMPYIPPVFTIGTTEFFDAWFDALQDRVAKRRIQARIDRLATGNPGDWKSVGAPVVEMRIDHGPGYRVYYAQRE
SAWVILLCGGDKSTQQADIRAAHAMLEHLDTE

Nucleotide

• Length: 339 bp

>T75350 NZ_CP020738:c940155-939817 [Paraburkholderia acidophila]
ATGGTTGACACACTGCTATCGATGCCCTACATTCCTCCTGTATTCACCATCGGAACCACCGAGTTCTTCGACGCATGGTT
CGACGCGCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCGCGCATCGACCGGCTGGCGACGGGCAACCCTGGCGACT
GGAAGTCCGTCGGCGCGCCGGTCGTCGAAATGCGCATCGACCATGGCCCGGGCTATCGCGTCTACTATGCGCAGCGGGAA
TCGGCATGGGTGATCCTGCTGTGCGGCGGCGACAAGTCGACGCAACAGGCGGACATACGGGCTGCGCATGCGATGCTCGA
GCATCTCGATACGGAGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10746.21 Da
• Isoelectric Point: 6.6390

>AT75350 WP_059851409.1 NZ_CP020738:c939813-939514 [Paraburkholderia acidophila]
MDKIKTRPWDSAEHLKTEDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHV

Nucleotide

• Length: 300 bp

>AT75350 NZ_CP020738:c939813-939514 [Paraburkholderia acidophila]
ATGGACAAGATCAAGACCCGGCCATGGGATTCGGCCGAACACCTGAAGACCGAAGACGACATGGCCGAGTACTTCGAAGC
CTGTCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCGCGTGCGCGCGGCATGTCAC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGCCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2A4FM99