Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1537646..1538240 Replicon chromosome
Accession NZ_CP020645
Organism Bordetella bronchiseptica strain I943

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag B7P02_RS07255 Protein ID WP_003819882.1
Coordinates 1538058..1538240 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag B7P02_RS07250 Protein ID WP_003819880.1
Coordinates 1537646..1538035 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P02_RS07225 1533488..1534528 + 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -
B7P02_RS07230 1534663..1535679 + 1017 WP_003809636.1 phosphate ABC transporter permease subunit PstC -
B7P02_RS07235 1535701..1536558 + 858 WP_003809638.1 phosphate ABC transporter permease PstA -
B7P02_RS07240 1536603..1537379 + 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
B7P02_RS07250 1537646..1538035 - 390 WP_003819880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B7P02_RS07255 1538058..1538240 - 183 WP_003819882.1 type II toxin-antitoxin system HicA family toxin Toxin
B7P02_RS07260 1538648..1539346 + 699 WP_015041235.1 gluconate 2-dehydrogenase subunit 3 family protein -
B7P02_RS07265 1539350..1541119 + 1770 WP_004568200.1 GMC family oxidoreductase -
B7P02_RS07270 1541130..1542485 + 1356 WP_004568199.1 cytochrome c -
B7P02_RS07275 1542496..1543236 - 741 WP_004568198.1 carbonic anhydrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.91 Da        Isoelectric Point: 11.4375

>T75205 WP_003819882.1 NZ_CP020645:c1538240-1538058 [Bordetella bronchiseptica]
MNSADLIKRLKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKDLPTATQRSILKQAGLR

Download         Length: 183 bp

>T75205 NZ_CP020645:c1538240-1538058 [Bordetella bronchiseptica]
ATGAACAGCGCAGACCTGATCAAGCGACTGAAGGCAGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGACCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14300.00 Da        Isoelectric Point: 4.3864

>AT75205 WP_003819880.1 NZ_CP020645:c1538035-1537646 [Bordetella bronchiseptica]
MLYPIHVSKDEGSAYGAVFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYRGGYWMMVDID
LSKVSTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT75205 NZ_CP020645:c1538035-1537646 [Bordetella bronchiseptica]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGTCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCGAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAGCACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAACACGAAATGGCCGACGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References