Detailed information of TA system TA075164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 47215..47873
• Replicon: plasmid p15A34_1
• Accession: NZ_CP020589
• Organism: Acinetobacter baumannii strain 15A34

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: B7L42_RS00315
• Protein ID: WP_000312250.1
• Coordinates: 47514..47873 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: B7L42_RS00310
• Protein ID: WP_001096429.1
• Coordinates: 47215..47514 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L42_RS00260	42248..42505	+	258	WP_000834292.1	hypothetical protein	-
B7L42_RS00265	42510..43082	+	573	WP_000429351.1	hypothetical protein	-
B7L42_RS00270	43058..43237	+	180	WP_002081921.1	hypothetical protein	-
B7L42_RS00275	43254..43883	+	630	WP_002081923.1	hypothetical protein	-
B7L42_RS00280	43923..44432	+	510	WP_001043199.1	hypothetical protein	-
B7L42_RS00285	44513..45067	+	555	WP_000790085.1	hypothetical protein	-
B7L42_RS00290	45117..45653	+	537	WP_000731981.1	hypothetical protein	-
B7L42_RS00300	46276..46758	+	483	WP_001052677.1	hypothetical protein	-
B7L42_RS00305	46851..47114	-	264	WP_000110863.1	hypothetical protein	-
B7L42_RS00310	47215..47514	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
B7L42_RS00315	47514..47873	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7L42_RS00320	48074..48640	+	567	WP_041171756.1	hypothetical protein	-
B7L42_RS00325	48689..48871	+	183	WP_000373385.1	hypothetical protein	-
B7L42_RS00330	48938..49636	+	699	WP_000873190.1	hypothetical protein	-
B7L42_RS00335	49775..50158	+	384	WP_000654349.1	hypothetical protein	-
B7L42_RS00340	50225..50983	+	759	WP_001053129.1	hypothetical protein	-
B7L42_RS00350	52053..52367	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..72076	72076

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T75164 WP_000312250.1 NZ_CP020589:c47873-47514 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T75164 NZ_CP020589:c47873-47514 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT75164 WP_001096429.1 NZ_CP020589:c47514-47215 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT75164 NZ_CP020589:c47514-47215 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA