Detailed information of TA system TA074718

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2070632..2070931
• Replicon: chromosome
• Accession: NZ_CP020467
• Organism: Staphylococcus aureus strain CFSAN007896

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AB477_RS10530
• Protein ID: WP_011447039.1
• Coordinates: 2070755..2070931 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2070632..2070687 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB477_RS10485	2065963..2066223	+	261	WP_001791826.1	hypothetical protein	-
AB477_RS10490	2066276..2066626	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AB477_RS10495	2067311..2067760	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AB477_RS10500	2067855..2068190	-	336	Protein_1950	SH3 domain-containing protein	-
AB477_RS10510	2068840..2069331	-	492	WP_000919350.1	staphylokinase	-
AB477_RS10515	2069522..2070277	-	756	WP_107375239.1	CHAP domain-containing protein	-
AB477_RS10520	2070289..2070543	-	255	WP_000611512.1	phage holin	-
AB477_RS10525	2070595..2070702	+	108	WP_001791821.1	hypothetical protein	-
-	2070624..2070763	+	140	NuclAT_0	-	-
-	2070624..2070763	+	140	NuclAT_0	-	-
-	2070624..2070763	+	140	NuclAT_0	-	-
-	2070624..2070763	+	140	NuclAT_0	-	-
-	2070632..2070687	+	56	-	-	Antitoxin
AB477_RS10530	2070755..2070931	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AB477_RS10535	2071081..2071377	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AB477_RS10540	2071435..2071722	-	288	WP_001040261.1	hypothetical protein	-
AB477_RS10545	2071769..2071921	-	153	WP_001153681.1	hypothetical protein	-
AB477_RS10550	2071911..2075696	-	3786	WP_107375240.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / tsst-1 / groEL	2060529..2131804	71275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T74718 WP_011447039.1 NZ_CP020467:c2070931-2070755 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T74718 NZ_CP020467:c2070931-2070755 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT74718 NZ_CP020467:2070632-2070687 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin