Detailed information of TA system TA074666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 720878..721564
• Replicon: chromosome
• Accession: NZ_CP020419
• Organism: Neisseria gonorrhoeae strain FDAARGOS_207

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: A6J46_RS04380
• Protein ID: WP_003689143.1
• Coordinates: 720878..721060 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: A6J46_RS04385
• Protein ID: WP_003691454.1
• Coordinates: 721163..721564 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J46_RS04340	716109..717143	-	1035	WP_082298682.1	helix-turn-helix domain-containing protein	-
A6J46_RS04345	717140..717367	-	228	WP_003691442.1	helix-turn-helix domain-containing protein	-
A6J46_RS04350	717541..717729	+	189	WP_003706568.1	hypothetical protein	-
A6J46_RS04355	717706..717861	-	156	WP_047923772.1	hypothetical protein	-
A6J46_RS04360	717942..718130	-	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
A6J46_RS04365	718246..718956	+	711	WP_025455899.1	helix-turn-helix transcriptional regulator	-
A6J46_RS04370	719195..719893	+	699	WP_003689139.1	hypothetical protein	-
A6J46_RS04375	719890..720708	+	819	WP_025455900.1	DUF3037 domain-containing protein	-
A6J46_RS04380	720878..721060	+	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
A6J46_RS04385	721163..721564	+	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A6J46_RS04390	721662..722444	-	783	WP_003689146.1	hypothetical protein	-
A6J46_RS04395	722634..722828	+	195	WP_082298683.1	hypothetical protein	-
A6J46_RS04400	722969..723301	+	333	WP_105211374.1	hypothetical protein	-
A6J46_RS04405	723454..723729	+	276	WP_003695501.1	hypothetical protein	-
A6J46_RS04410	723726..723887	+	162	WP_004464809.1	hypothetical protein	-
A6J46_RS04415	723956..724642	+	687	WP_010357532.1	hypothetical protein	-
A6J46_RS04420	724782..724964	+	183	WP_003691535.1	hypothetical protein	-
A6J46_RS04425	724961..725452	+	492	WP_082298684.1	siphovirus Gp157 family protein	-
A6J46_RS04430	725504..725719	+	216	WP_003691538.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	705451..736709	31258

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T74666 WP_003689143.1 NZ_CP020419:720878-721060 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T74666 NZ_CP020419:720878-721060 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT74666 WP_003691454.1 NZ_CP020419:721163-721564 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT74666 NZ_CP020419:721163-721564 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2