Detailed information of TA system TA074603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1531852..1532386
• Replicon: chromosome
• Accession: NZ_CP020398
• Organism: Burkholderia multivorans strain FDAARGOS_246

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: A8H40_RS23830
• Protein ID: WP_006411826.1
• Coordinates: 1531852..1532151 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: A8H40_RS23835
• Protein ID: WP_006397060.1
• Coordinates: 1532141..1532386 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H40_RS23815	1527429..1528556	-	1128	WP_006403536.1	VOC family protein	-
A8H40_RS23820	1528911..1530218	+	1308	WP_006411823.1	shikimate transporter	-
A8H40_RS23825	1530442..1531743	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
A8H40_RS23830	1531852..1532151	-	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8H40_RS23835	1532141..1532386	-	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A8H40_RS23840	1532526..1533296	+	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
A8H40_RS23845	1533335..1535635	-	2301	WP_006411821.1	ATP-dependent DNA helicase	-
A8H40_RS23850	1535632..1537335	-	1704	WP_006411824.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T74603 WP_006411826.1 NZ_CP020398:c1532151-1531852 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T74603 NZ_CP020398:c1532151-1531852 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGTCTTACACGTACAA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT74603 WP_006397060.1 NZ_CP020398:c1532386-1532141 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT74603 NZ_CP020398:c1532386-1532141 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGACCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Structures

Antitoxin

• AlphaFold DB: B9B0C2