Detailed information of TA system TA074588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1074454..1075091
• Replicon: chromosome
• Accession: NZ_CP020394
• Organism: Burkholderia vietnamiensis strain FDAARGOS_239

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1G5N4H6
• Locus tag: A8H33_RS05765
• Protein ID: WP_034192973.1
• Coordinates: 1074454..1074855 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: A8H33_RS05770
• Protein ID: WP_045578624.1
• Coordinates: 1074855..1075091 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H33_RS05755	1071831..1072967	+	1137	WP_045578623.1	alginate lyase family protein	-
A8H33_RS05760	1072998..1074386	+	1389	WP_014722202.1	L-serine ammonia-lyase	-
A8H33_RS05765	1074454..1074855	-	402	WP_034192973.1	type II toxin-antitoxin system VapC family toxin	Toxin
A8H33_RS05770	1074855..1075091	-	237	WP_045578624.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
A8H33_RS05775	1075370..1077073	+	1704	WP_045578625.1	thiamine pyrophosphate-binding protein	-
A8H33_RS05780	1077070..1078191	+	1122	WP_045578626.1	ADP-heptose--LPS heptosyltransferase	-
A8H33_RS05785	1078316..1079350	-	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14848.01 Da
• Isoelectric Point: 5.1682

>T74588 WP_034192973.1 NZ_CP020394:c1074855-1074454 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITCAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T74588 NZ_CP020394:c1074855-1074454 [Burkholderia vietnamiensis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACTTGATGAAGAGCCAGCCCGAGCAAGTGGCGAAGCGATTTGC
GCAGTGCTACACGGGCGACGTCGTGATGTCGGCGATCACGTGTGCCGAGCTGGAGTACGGCGTCACCGCTTGCGCGGCGC
CCGCGCGTGAGCGCCGCCATCTTGCGGCGCTGATCGAGGATATTCCCGTCGCGCCGTTCGACGCCGCGGCCGCGCAAGCA
TATGGGCCCGTGCGTGACGCAACGCGCGCATGGAAGAAGGATCATCTCGACAAACTGATCGCCGCTCATGCGGTGTCGCT
CGATGTCGTGCTGGTGACGAATGACGAGCGCGATTTCACGAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9022.15 Da
• Isoelectric Point: 5.7316

>AT74588 WP_045578624.1 NZ_CP020394:c1075091-1074855 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT74588 NZ_CP020394:c1075091-1074855 [Burkholderia vietnamiensis]
ATGCATACCACGAGGGTATTTCGGAACGGCAATTCGCAGGCCGTGCGAATTCCTGCGGATCTCGCTTATGAGCGCAGCGA
TATCGAGCTCGAGATCGAGCGCATCGGCGACGAGATTCGCATCCGGCCGGCGCGACGGCCGTTGACGCAGGTGCTCGAGA
AGTTCGCGAAGTTCGCGCCCGATTTCATGGCGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGGTTGTGA

Structures

Toxin

• AlphaFold DB: A0A1G5N4H6