Detailed information of TA system TA074463

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1426255..1426475
• Replicon: chromosome
• Accession: NZ_CP020378
• Organism: Clostridioides difficile strain DSM 102859

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: -
• Locus tag: CDIF102859_RS20410
• Protein ID: WP_032547262.1
• Coordinates: 1426255..1426416 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1426336..1426475 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF102859_RS07075	1421522..1421752	+	231	Protein_1275	hypothetical protein	-
CDIF102859_RS07080	1421825..1422226	+	402	WP_022618353.1	hypothetical protein	-
CDIF102859_RS07085	1422220..1422582	+	363	WP_021374925.1	hypothetical protein	-
CDIF102859_RS07090	1422582..1423007	+	426	WP_021374903.1	HK97 gp10 family phage protein	-
CDIF102859_RS07095	1423000..1423437	+	438	WP_021374962.1	hypothetical protein	-
CDIF102859_RS07100	1423430..1423606	+	177	WP_021374845.1	hypothetical protein	-
CDIF102859_RS07105	1423607..1424917	+	1311	WP_021374966.1	phage tail sheath family protein	-
CDIF102859_RS07110	1424934..1425404	+	471	WP_021374876.1	phage tail tube protein	-
CDIF102859_RS07115	1425474..1425914	+	441	WP_021374842.1	phage XkdN-like family protein	-
CDIF102859_RS20410	1426255..1426416	+	162	WP_032547262.1	hypothetical protein	Toxin
-	1426336..1426475	-	140	NuclAT_3	-	Antitoxin
-	1426336..1426475	-	140	NuclAT_4	-	Antitoxin
CDIF102859_RS07125	1427880..1428062	+	183	WP_021374885.1	hypothetical protein	-
CDIF102859_RS07130	1428183..1428995	+	813	WP_077709172.1	toxin Bro	-
CDIF102859_RS20290	1429050..1429217	+	168	WP_021374752.1	hypothetical protein	-
CDIF102859_RS07135	1429339..1430112	+	774	WP_065987070.1	SHOCT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6092.32 Da
• Isoelectric Point: 10.8232

>T74463 WP_032547262.1 NZ_CP020378:1426255-1426416 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELDFKIKFRKFK

Nucleotide

• Length: 162 bp

>T74463 NZ_CP020378:1426255-1426416 [Clostridioides difficile]
ATGGACAACTTTTTACTTAGTATATTAGCTAGCTTGATAGCTAGTTTAATTGGATATATCGTTTGTAGATGTATCAAAAA
CGTAAAAAGCCACTCTACTCGTGGCAAGAGTAAAAGTGGCTGGGAACTTGATTTTAAAATAAAGTTCCGCAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT74463 NZ_CP020378:c1426475-1426336 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAATCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Antitoxin