Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2158557..2159179 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYE8
Locus tag B4X03_RS10390 Protein ID WP_005715063.1
Coordinates 2158997..2159179 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A836MEP4
Locus tag B4X03_RS10385 Protein ID WP_021113997.1
Coordinates 2158557..2158970 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS10340 2153741..2154409 - 669 WP_021113990.1 S24 family peptidase -
B4X03_RS10345 2154552..2154767 + 216 WP_021113991.1 Cro/CI family transcriptional regulator -
B4X03_RS10350 2154788..2155033 + 246 WP_021118902.1 CII family transcriptional regulator -
B4X03_RS10355 2155073..2155758 + 686 Protein_2009 phage antirepressor KilAC domain-containing protein -
B4X03_RS10360 2155755..2156540 + 786 WP_021110739.1 replication protein -
B4X03_RS10365 2156540..2157211 + 672 WP_082259387.1 replication protein P -
B4X03_RS10370 2157212..2157772 + 561 WP_078208831.1 DNA N-6-adenine-methyltransferase -
B4X03_RS10380 2158074..2158523 + 450 WP_080698141.1 recombination protein NinB -
B4X03_RS10385 2158557..2158970 - 414 WP_021113997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B4X03_RS10390 2158997..2159179 - 183 WP_005715063.1 type II toxin-antitoxin system HicA family toxin Toxin
B4X03_RS11725 2159279..2159455 + 177 WP_202115193.1 hypothetical protein -
B4X03_RS10395 2159427..2160005 + 579 WP_035522926.1 recombination protein NinG -
B4X03_RS10400 2159995..2160456 + 462 WP_035522928.1 antiterminator Q family protein -
B4X03_RS10410 2160714..2161013 + 300 WP_198525434.1 hypothetical protein -
B4X03_RS10415 2160988..2161533 + 546 WP_021114001.1 lysozyme -
B4X03_RS10420 2161506..2161850 + 345 WP_021114002.1 DUF2570 family protein -
B4X03_RS10430 2162415..2162930 + 516 WP_021118468.1 terminase small subunit -
B4X03_RS10435 2162914..2164149 + 1236 WP_082259388.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2141343..2184938 43595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6678.80 Da        Isoelectric Point: 10.6602

>T74000 WP_005715063.1 NZ_CP020085:c2159179-2158997 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Download         Length: 183 bp

>T74000 NZ_CP020085:c2159179-2158997 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATCAAAATGATTGAAGCAGATGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCCAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15277.32 Da        Isoelectric Point: 4.3689

>AT74000 WP_021113997.1 NZ_CP020085:c2158970-2158557 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEDIPLPTSIENHRNNPDFTDYGMFF
GIVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT74000 NZ_CP020085:c2158970-2158557 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGACATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTATTTCACCTTGAAGGCTTAGTTGAAG
ATGGCGAAGATATTCCATTACCAACGAGTATCGAAAATCACCGTAACAACCCTGATTTTACCGATTACGGTATGTTCTTT
GGGATTGTTGATGTTGATATTAGCCATTTACTAGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYE8

Antitoxin

Source ID Structure
AlphaFold DB A0A836MEP4

References