Detailed information of TA system TA073988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2279000..2279559
• Replicon: chromosome
• Accession: NZ_CP020083
• Organism: Blastomonas fulva strain T2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U2YAE2
• Locus tag: B5J99_RS10710
• Protein ID: WP_021691169.1
• Coordinates: 2279266..2279559 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B5J99_RS10705
• Protein ID: WP_021691170.1
• Coordinates: 2279000..2279269 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5J99_RS10690	2274387..2275226	-	840	WP_021691173.1	DUF945 domain-containing protein	-
B5J99_RS10695	2275514..2275813	-	300	WP_021691172.1	DUF736 domain-containing protein	-
B5J99_RS10700	2276482..2278536	-	2055	WP_021691171.1	ParB/RepB/Spo0J family partition protein	-
B5J99_RS10705	2279000..2279269	+	270	WP_021691170.1	ribbon-helix-helix domain-containing protein	Antitoxin
B5J99_RS10710	2279266..2279559	+	294	WP_021691169.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B5J99_RS10715	2279675..2279929	+	255	WP_021691168.1	hypothetical protein	-
B5J99_RS10720	2279948..2281579	+	1632	WP_117352368.1	recombinase family protein	-
B5J99_RS10730	2281728..2282363	-	636	WP_117352369.1	adenylate/guanylate cyclase domain-containing protein	-
B5J99_RS10735	2282484..2283485	+	1002	WP_117353460.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	acpXL	2106892..2280901	174009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11474.10 Da
• Isoelectric Point: 7.2779

>T73988 WP_021691169.1 NZ_CP020083:2279266-2279559 [Blastomonas fulva]
MRIKWTGKASSDLVRLHEHLRPVAPEAAARVVQQLSRAPDRLLDYPRIGEKLDAYEPREVRRIIVGNYELRYEIADATIF
ILRLWHCREERSFESDD

Nucleotide

• Length: 294 bp

>T73988 NZ_CP020083:2279266-2279559 [Blastomonas fulva]
ATGAGGATCAAGTGGACCGGCAAGGCGTCCTCGGATTTGGTGCGGCTGCACGAGCATCTGCGTCCGGTTGCCCCGGAGGC
GGCGGCGCGGGTCGTGCAGCAGCTCTCGCGCGCGCCGGATCGGCTGCTCGACTATCCCCGGATCGGCGAGAAGCTGGACG
CCTACGAGCCGCGCGAGGTTCGGCGCATCATCGTCGGCAATTACGAGCTGCGCTACGAGATTGCGGATGCGACGATCTTC
ATCCTGCGCCTGTGGCATTGCCGCGAGGAGCGCAGCTTCGAGTCGGACGACTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9914.26 Da
• Isoelectric Point: 5.1167

>AT73988 WP_021691170.1 NZ_CP020083:2279000-2279269 [Blastomonas fulva]
MATETKVLTAHVPLHLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEAMEDVDAGRVIDHQAVRAWADSLGT
DTPLPPPSA

Nucleotide

• Length: 270 bp

>AT73988 NZ_CP020083:2279000-2279269 [Blastomonas fulva]
ATGGCGACTGAGACAAAAGTGTTGACCGCACACGTCCCGCTGCACCTCGCGGAGAAGGTTGAAGCAATGGCCTCGCGGCT
CGAACGCTCGCGTGGCTGGGTGATGAAACAGGCGCTCGCCGCCTGGGTTGATCAGGAGGAGGAGCGTCACCGCATGACGC
TCGAAGCAATGGAAGATGTCGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCGCGCTTGGGCGGACAGCCTCGGCACT
GACACCCCGCTGCCGCCGCCTTCGGCATGA

Structures

Toxin

• AlphaFold DB: U2YAE2