Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1095794..1096328 Replicon chromosome
Accession NZ_CP020013
Organism Haemophilus influenzae strain 6P32H1

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BV140_RS05560 Protein ID WP_005651512.1
Coordinates 1095794..1096084 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BV140_RS05565 Protein ID WP_005651514.1
Coordinates 1096074..1096328 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV140_RS05545 1093150..1093653 + 504 WP_005659127.1 hypothetical protein -
BV140_RS05550 1093653..1094687 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BV140_RS09495 1095197..1095334 - 138 WP_005659136.1 hypothetical protein -
BV140_RS05555 1095504..1095713 - 210 WP_074030365.1 hypothetical protein -
BV140_RS05560 1095794..1096084 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV140_RS05565 1096074..1096328 - 255 WP_005651514.1 stability protein StbD Antitoxin
BV140_RS05575 1096626..1096850 - 225 WP_005659141.1 hypothetical protein -
BV140_RS05580 1096850..1097158 - 309 WP_005659142.1 P2 family phage major capsid protein -
BV140_RS05585 1097188..1097727 - 540 WP_005659144.1 hypothetical protein -
BV140_RS05595 1098089..1100155 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BV140_RS05600 1100493..1100858 - 366 WP_005686191.1 endonuclease domain-containing protein -
BV140_RS05605 1100888..1101148 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T73746 WP_005651512.1 NZ_CP020013:c1096084-1095794 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T73746 NZ_CP020013:c1096084-1095794 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT73746 WP_005651514.1 NZ_CP020013:c1096328-1096074 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT73746 NZ_CP020013:c1096328-1096074 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References