Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1473326..1474026 Replicon chromosome
Accession NZ_CP019934
Organism Bordetella bronchiseptica strain E016

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3LPJ8
Locus tag B2C13_RS06980 Protein ID WP_003809515.1
Coordinates 1473326..1473622 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag B2C13_RS06985 Protein ID WP_003809516.1
Coordinates 1473625..1474026 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2C13_RS06960 1469622..1470164 + 543 WP_010926149.1 molybdenum cofactor biosysynthesis protein -
B2C13_RS06965 1470340..1471404 + 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
B2C13_RS06970 1471490..1471936 - 447 WP_003809511.1 GFA family protein -
B2C13_RS06975 1472162..1473043 + 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
B2C13_RS06980 1473326..1473622 + 297 WP_003809515.1 type II toxin-antitoxin system MqsR family toxin Toxin
B2C13_RS06985 1473625..1474026 + 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
B2C13_RS06990 1474046..1474282 + 237 WP_003809519.1 hypothetical protein -
B2C13_RS06995 1474290..1474769 + 480 WP_003809523.1 disulfide bond formation protein B -
B2C13_RS07000 1474917..1475432 + 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
B2C13_RS07005 1475435..1476625 + 1191 WP_003809527.1 5-(carboxyamino)imidazole ribonucleotide synthase -
B2C13_RS07010 1476645..1477682 + 1038 WP_003809529.1 threonylcarbamoyl-AMP synthase -
B2C13_RS07015 1477819..1478847 + 1029 WP_033447398.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10608.50 Da        Isoelectric Point: 7.9291

>T73505 WP_003809515.1 NZ_CP019934:1473326-1473622 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

>T73505 NZ_CP019934:1473326-1473622 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT73505 WP_003809516.1 NZ_CP019934:1473625-1474026 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT73505 NZ_CP019934:1473625-1474026 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3LPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References