Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2179837..2180033 Replicon chromosome
Accession NZ_CP019864
Organism Clostridioides difficile strain DSM 29747

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag CDIF29747_RS10585 Protein ID WP_003424190.1
Coordinates 2179881..2180033 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2179837..2179937 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29747_RS10570 2175104..2175361 - 258 WP_003424182.1 hypothetical protein -
CDIF29747_RS10575 2175348..2175581 - 234 WP_003424184.1 hypothetical protein -
CDIF29747_RS10580 2175769..2175957 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
- 2179837..2179937 + 101 NuclAT_0 - Antitoxin
CDIF29747_RS10585 2179881..2180033 - 153 WP_003424190.1 hypothetical protein Toxin
CDIF29747_RS10590 2180553..2180795 + 243 WP_003424191.1 hypothetical protein -
CDIF29747_RS10595 2180861..2181406 + 546 WP_077699404.1 site-specific integrase -
CDIF29747_RS10600 2181951..2182796 + 846 WP_003424194.1 DUF4878 domain-containing protein -
CDIF29747_RS10605 2183020..2183184 - 165 WP_003424195.1 hypothetical protein -
CDIF29747_RS10610 2183716..2184047 - 332 Protein_1948 carboxymuconolactone decarboxylase family protein -
CDIF29747_RS10615 2184307..2184948 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(40) - 1956727..2261853 305126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T73386 WP_003424190.1 NZ_CP019864:c2180033-2179881 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

>T73386 NZ_CP019864:c2180033-2179881 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin


Download         Length: 101 bp

>AT73386 NZ_CP019864:2179837-2179937 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References