Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2758069..2758278 Replicon chromosome
Accession NZ_CP019860
Organism Clostridioides difficile strain DSM 29632

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF29632_RS13125 Protein ID WP_004454815.1
Coordinates 2758120..2758278 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2758069..2758203 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29632_RS13110 2753894..2755522 + 1629 WP_009897704.1 aspartate 4-decarboxylase -
CDIF29632_RS13115 2755643..2756638 + 996 WP_003431031.1 asparaginase -
CDIF29632_RS13120 2756827..2757210 - 384 Protein_2438 BlaI/MecI/CopY family transcriptional regulator -
- 2758069..2758203 + 135 NuclAT_2 - Antitoxin
CDIF29632_RS13125 2758120..2758278 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF29632_RS13130 2758637..2760007 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
CDIF29632_RS13135 2760290..2760388 + 99 Protein_2441 Arm DNA-binding domain-containing protein -
CDIF29632_RS13140 2760407..2760828 + 422 Protein_2442 hypothetical protein -
CDIF29632_RS13145 2761059..2761331 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
CDIF29632_RS13150 2761649..2762317 - 669 WP_021361938.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T73379 WP_004454815.1 NZ_CP019860:c2758278-2758120 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T73379 NZ_CP019860:c2758278-2758120 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT73379 NZ_CP019860:2758069-2758203 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References