Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1341117..1341322 Replicon chromosome
Accession NZ_CP019858
Organism Clostridioides difficile strain DSM 29688

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CDIF29688_RS06760 Protein ID WP_009896140.1
Coordinates 1341117..1341269 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1341249..1341322 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF29688_RS06740 1336579..1336863 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CDIF29688_RS06745 1336886..1338403 - 1518 WP_011861147.1 recombinase family protein -
CDIF29688_RS06750 1338528..1339349 - 822 WP_021390130.1 tetratricopeptide repeat protein -
CDIF29688_RS06755 1339540..1340967 + 1428 WP_021366431.1 cell wall-binding protein Cwp26 -
CDIF29688_RS06760 1341117..1341269 + 153 WP_009896140.1 hypothetical protein Toxin
- 1341249..1341322 - 74 NuclAT_14 - Antitoxin
CDIF29688_RS06765 1342636..1342860 - 225 WP_021366542.1 helix-turn-helix domain-containing protein -
CDIF29688_RS06780 1343939..1344190 + 252 WP_003419270.1 hypothetical protein -
CDIF29688_RS06790 1344820..1345029 + 210 WP_009902373.1 hypothetical protein -
CDIF29688_RS06795 1345398..1345781 - 384 WP_003433385.1 hypothetical protein -
CDIF29688_RS06800 1345908..1346252 + 345 WP_021390131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T73352 WP_009896140.1 NZ_CP019858:1341117-1341269 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T73352 NZ_CP019858:1341117-1341269 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTTAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT73352 NZ_CP019858:c1341322-1341249 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References