Detailed information of TA system TA073352

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1341117..1341322
• Replicon: chromosome
• Accession: NZ_CP019858
• Organism: Clostridioides difficile strain DSM 29688

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: CDIF29688_RS06760
• Protein ID: WP_009896140.1
• Coordinates: 1341117..1341269 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1341249..1341322 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF29688_RS06740	1336579..1336863	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
CDIF29688_RS06745	1336886..1338403	-	1518	WP_011861147.1	recombinase family protein	-
CDIF29688_RS06750	1338528..1339349	-	822	WP_021390130.1	tetratricopeptide repeat protein	-
CDIF29688_RS06755	1339540..1340967	+	1428	WP_021366431.1	cell wall-binding protein Cwp26	-
CDIF29688_RS06760	1341117..1341269	+	153	WP_009896140.1	hypothetical protein	Toxin
-	1341249..1341322	-	74	NuclAT_14	-	Antitoxin
CDIF29688_RS06765	1342636..1342860	-	225	WP_021366542.1	helix-turn-helix domain-containing protein	-
CDIF29688_RS06780	1343939..1344190	+	252	WP_003419270.1	hypothetical protein	-
CDIF29688_RS06790	1344820..1345029	+	210	WP_009902373.1	hypothetical protein	-
CDIF29688_RS06795	1345398..1345781	-	384	WP_003433385.1	hypothetical protein	-
CDIF29688_RS06800	1345908..1346252	+	345	WP_021390131.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T73352 WP_009896140.1 NZ_CP019858:1341117-1341269 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T73352 NZ_CP019858:1341117-1341269 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTTAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT73352 NZ_CP019858:c1341322-1341249 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin